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Amino-PEG9-amine

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Category Small-molecule Homobifunctional PEG
Catalog NO. BPG-2195
Product Name Amino-PEG9-amine
CAS 474082-35-4
Molecular Formula C₂₀H₄₄N₂O₉
Molecular Weight 456.57
Amino-PEG9-amine
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Product Information

Description Amino-PEG9-amine is a polyethylene glycol (PEG)-based PROTAC linker. Amino-PEG9-amine can be used in the synthesis of a series of PROTACs.
Synonyms H2N-PEG9-CH2CH2NH2; 3,6,9,12,15,18,21,24,27-Nonaoxanonacosane-1,29-diamine
IUPAC Name 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Canonical SMILES C(COCCOCCOCCOCCOCCOCCOCCOCCOCCN)N
InChI InChI=1S/C20H44N2O9/c21-1-3-23-5-7-25-9-11-27-13-15-29-17-19-31-20-18-30-16-14-28-12-10-26-8-6-24-4-2-22/h1-22H2
InChIKey YWYRXJJAEDMZGY-UHFFFAOYSA-N
Boiling Point 527.4±45.0 °C at 760 mmHg
Purity >97%
Density 1.1±0.1 g/cm3
Appearance Colorless Liquid
Storage Please store the product under the recommended conditions in the Certificate of Analysis.

Amino-PEG9-amine, a remarkably versatile compound with multifaceted applications in bioscience and interconnected domains, showcases a plethora of functionalities. Here are four key applications of Amino-PEG9-amine depicted with heightened levels of perplexity and burstiness:

Drug Delivery: Spearheading the domain of drug delivery systems, Amino-PEG9-amine assumes a pivotal role in enhancing the solubility and stability of hydrophobic drugs. Its functional groups facilitate the conjugation of therapeutic agents, thereby augmenting precision and efficacy in targeting.

Bioconjugation: Within the intricate realm of bioconjugation chemistry, Amino-PEG9-amine emerges as a critical linker that enables the attachment of a diverse range of biomolecules—spanning from proteins and peptides to antibodies—to surfaces or other molecular entities. The PEG moiety bestows desired flexibility and hydrophilicity, mitigating immunogenic responses and enhancing biocompatibility.

Surface Modification: Upon delving into the realm of surface modification, Amino-PEG9-amine serves as a vital tool in refining the surfaces of nanoparticles, microarrays, and biosensors to reduce nonspecific binding while boosting specificity. The PEG chain imparts steric hindrance that minimizes unwanted protein adsorption and cellular interactions, elevating the performance and reliability of biomedical devices.

Tissue Engineering: In the intricate field of tissue engineering, Amino-PEG9-amine emerges as a key protagonist in functionalizing biomaterial scaffolds to promote optimal cell attachment and proliferation. The unique amino groups facilitate the grafting of bioactive molecules onto scaffolds, intensifying interactions with cells and paving the way for enhanced tissue regeneration and repair strategies.

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