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Hydroxy-PEG2-t-butyl acetate

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Category	Small-molecule Group Protected PEG
Catalog NO.	BPG-1771
Product Name	Hydroxy-PEG2-t-butyl acetate
CAS	149299-82-1
Molecular Formula	C10H20O5
Molecular Weight	220.26

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Description	Hydroxy-PEG2-CH2CO2tBu was a useful reagent in the study for potentiator-corrector agonist of cystic fibrosis mutant protein ΔF508-CFTR preparation.
Synonyms	2-[2-(2-hydroxyethoxy)ethoxy]acetic acid tert-butyl ester; tert-butyl 2-[2-(2-hydroxyethoxy)ethoxy]acetate
IUPAC Name	tert-butyl 2-[2-(2-hydroxyethoxy)ethoxy]acetate
Canonical SMILES	CC(C)(C)OC(=O)COCCOCCO
InChI	InChI=1S/C10H20O5/c1-10(2,3)15-9(12)8-14-7-6-13-5-4-11/h11H,4-8H2,1-3H3
InChIKey	LMDJRQVQNFNFAK-UHFFFAOYSA-N
Boiling Point	306.1±22.0 °C at 760 mmHg
Purity	>95%
Density	1.1±0.1 g/cm3
Appearance	Transparent Liquid
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Exact Mass	220.13107373
LogP	0.35360
Pictogram(s)	Irritant
Signal	Warning
Precautionary Statement Codes	P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hydroxy-PEG2-t-butyl acetate, a versatile chemical compound with wide-ranging biotechnological and pharmaceutical applications, plays a pivotal role in enhancing the solubility and stability of active pharmaceutical ingredients. Here are four key applications of Hydroxy-PEG2-t-butyl acetate, presented with a high degree of perplexity and burstiness:

Drug Formulation: In the intricate field of drug formulation, Hydroxy-PEG2-t-butyl acetate emerges as a crucial agent for enhancing the solubility and stability of active pharmaceutical ingredients. Its hydrophilic nature not only aids in improving the bioavailability of poorly soluble drugs but also enhances the efficacy and reliability of drug delivery systems, ushering in a new era of pharmaceutical innovation.

Surface Modification: In the realm of biomedical applications, Hydroxy-PEG2-t-butyl acetate assumes a pivotal role in the surface modification of nanoparticles and implants. By coating surfaces with this compound, scientists can enhance biocompatibility while simultaneously reducing protein adsorption and cell adhesion. This sophisticated modification technique fosters seamless integration of implants, thereby minimizing the risk of adverse immune reactions and pushing the boundaries of medical implant technology.

Polymer Chemistry: Delving into the realm of polymer chemistry, Hydroxy-PEG2-t-butyl acetate emerges as a foundational building block, particularly in the synthesis of PEGylated polymers. These polymers find extensive utility in the creation of hydrogels, micelles, and various drug delivery systems, offering a versatile solution for pharmaceutical and biotechnological applications. The adaptability of this compound enables the development of custom-designed materials with tailored properties, revolutionizing the landscape of polymer-based technologies.

Diagnostic Assays: Within the realm of diagnostics, Hydroxy-PEG2-t-butyl acetate takes center stage by being conjugated with diverse biomolecules to enhance their functionality in assays and sensors. Its pivotal role in improving the solubility of assay reagents and stabilizing proteins and enzymes leads to the development of more sensitive and reliable diagnostic tests, critical for the early detection and monitoring of diseases. This integration of Hydroxy-PEG2-t-butyl acetate in diagnostic assays marks a significant advancement in the field of medical diagnostics, showcasing its potential to revolutionize disease detection and management.

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