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C18-PEG12-NHS, PEG MW 528 Da

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Category C18-PEG-NHS
Catalog NO. BPG-0379
Product Name C18-PEG12-NHS, PEG MW 528 Da
C18-PEG12-NHS, PEG MW 528 Da
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Product Information

Description The PEG derivatives of the C18-PEG(n) series also belong to monodisperse PEG. It is a linear PEG derivative with 18 linear carbon straight chains and a different reactive group at the other end that can modify peptides, proteins, lipids or small molecules. The NHS ester can readily react with primary amines.As a drug crosslinker, it is widely used in medical research. Drug PEG modification can alter its dispersion and solubility in aqueous solutions. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system.
Synonyms Dodecaethylene glycol octadecyl succinimidyl ester
Solubility Soluble in water, DMSO and DMF. Freshly prepared before use.
Storage -20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
References 2. Zhu S, Niu M, O'Mary H, et al. Targeting of tumor-associated macrophages made possible by PEG-sheddable, mannose-modified nanoparticles. Molecular pharmaceutics, 2013, 10(9): 3525-3530.
1. Huang L, Song J, Chen B. A novel targeting drug carrier to deliver chemical bonded and physical entrapped anti-tumor drugs. International journal of pharmaceutics, 2014, 466(1-2): 52-57.


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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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