Biotin-PEG2-azide

Name: Biotin-PEG2-azide
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 945633-30-7

Cat No.: BPG-2090

Purity: >97%

4.5

Biotin-PEG2-CH2CH2N3 is a polyethylene glycol (PEG)-based PROTAC linker. Biotin-PEG2-CH2CH2N3 can be used in the synthesis of a series of PROTACs.

Category	Small-molecule Biotin PEG
Molecular Formula	C₁₆H₂₈N₆O₄S
Molecular Weight	400.50
Appearance	White Solid
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Powder, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month

Structure of 945633-30-7

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Synonyms	Biotin-PEG3-Azide;(+)-Biotin-PEG2-CH2CH2N3; Biotin-PEG2-CH2CH2N3
IUPACName	5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-(2-azidoethoxy)ethoxy]ethyl]pentanamide
CanonicalSMILES	C1C2C(C(S1)CCCCC(=O)NCCOCCOCCN=[N+]=[N-])NC(=O)N2
InChI	InChI=1S/C16H28N6O4S/c17-22-19-6-8-26-10-9-25-7-5-18-14(23)4-2-1-3-13-15-12(11-27-13)20-16(24)21-15/h12-13,15H,1-11H2,(H,18,23)(H2,20,21,24)/t12-,13-,15-/m0/s1
InChIKey	OVEZMVONEJMGLZ-YDHLFZDLSA-N
Purity	>97%
Solubility	Soluble in DMF, DMSO, moderately Soluble in water

ReactiveToward	Terminal Alkynes; Strained Alkynes (DBCO/BCN)
ReactionChemistry	CuAAC Click Chemistry; SPAAC Click Chemistry
BiomoleculeCompatibility	Biotin/Avidin Affinity Systems; Click-Handle-Modified Proteins / Peptides; Click-Handle-Modified Antibodies; Click-Handle-Modified Oligonucleotides; Small Molecules / Probes
ResearchUse	Copper-Free Azide–Cyclooctyne Ligation; Copper-Catalyzed Azide–Alkyne Ligation; Biotin / Desthiobiotin Affinity-Probe Construction