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Azido-PEG5-propionic acid
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| Category | Small-molecule Heterobifunctional PEG |
| Catalog NO. | BPG-1978 |
| Product Name | Azido-PEG5-propionic acid |
| CAS | 1425973-16-5 |
| Molecular Formula | C13H25N3O7 |
| Molecular Weight | 335.35 |
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| Description | Azido-PEG5-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| Synonyms | Azido-PEG5-acid;N3-PEG5-COOH; Azido-PEG5-C2-acid; Azido-PEG5-Acid; 1-Azido-3,6,9,12,15-pentaozaoctadecan-18-oic acid; 3-[(14-Azido-3,6,9,12-tetraoxatetradec-1-yl)oxy]propanoic acid |
| IUPAC Name | 3-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
| Canonical SMILES | C(COCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)O |
| InChI | InChI=1S/C13H25N3O7/c14-16-15-2-4-20-6-8-22-10-12-23-11-9-21-7-5-19-3-1-13(17)18/h1-12H2,(H,17,18) |
| InChIKey | DPJUPQILWDVIKK-UHFFFAOYSA-N |
| Purity | >98.0% |
| Solubility | Soluble in DMSO (10 mm) |
| Related CAS | 1167575-20-3 (polymer) |
| Appearance | Pale Yellow or Colorless Oily Liquid |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| Storage | Store at 2-8°C |
| LogP | -1.78 |
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Technical Information
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Industry News
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- FDA-Approved Antibody-Drug Conjugates up to 2024
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- Lipid Formulations: Key Absorption-Enhancing Technologies in New Drug Development
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- Liposome in Drug Delivery
- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
- PEG in Pharmaceutical Preparations (II): Stabilizers, Plasticizers and Modification Materials
- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated Drugs: Definition, Structure, Classification and Benefits
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Pharmacokinetics and Bioanalysis of PEGylated Drugs
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
- Vaccines: Definition, History, Ingredients, Types and Mechanism of Action
- What are Lipid Excipients and Their Applications?
- What are Lipid Nanoparticles and Their Applications?
- What are Lipid-Drug Conjugates (LDCs)?
- What are Lipids?
- What are Monodispersed and Polydispersed PEGs?
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PEGylation of Peptides
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Reduce the Immunogenicity of Peptide/Protein Drugs
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Improved Circulation Half-Life
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