| Category | Small-molecule Heterobifunctional PEG |
| Molecular Formula | C15H23N3O6S |
| Molecular Weight | 373.4 |
| Appearance | Transparent Liquid |
| Storage | Store at -20°C |
Azido-PEG4-Tos
Azido-PEG4-Tos is a heterobifunctional PEG linker containing an azide group and a tosyl group. The azide group reacts with terminal alkynes and cyclooctyne derivatives via click chemistry, and the tosyl group can be replaced by nuleophilic reagents for bioconjugation and PEGylation.
Structure of Azido-PEG4-Tos
Ordering Information
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- Specification
- Key Product Attributes
- Reaction & Conjugation Properties
| Synonyms | 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate |
| CanonicalSMILES | CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCN=[N+]=[N-] |
| InChI | InChI=1S/C15H23N3O6S/c1-14-2-4-15(5-3-14)25(19,20)24-13-12-23-11-10-22-9-8-21-7-6-17-18-16/h2-5H,6-13H2,1H3 |
| InChIKey | ZYZZLMAEZYMGEU-UHFFFAOYSA-N |
| Purity | >95% |
| PEGType | Discrete PEG Linker |
| PEGArchitecture | Linear |
| Functionality | Heterobifunctional |
| ReactiveToward | Terminal Alkynes; Strained Alkynes (DBCO/BCN); Nucleophiles (Amines / Thiols) |
| ReactionChemistry | CuAAC Click Chemistry; SPAAC Click Chemistry; Nucleophilic Substitution |
| BiomoleculeCompatibility | Click-Handle-Modified Proteins / Peptides; Click-Handle-Modified Antibodies; Click-Handle-Modified Oligonucleotides; Small Molecules / Probes; Amine- or Thiol-Functionalized Biomolecules |
| ResearchUse | Copper-Free Azide–Cyclooctyne Ligation; Copper-Catalyzed Azide–Alkyne Ligation; Nucleophilic Linker Substitution |
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