Azido-PEG10-Acid
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| Category | Azido-PEGn-Acid |
| Catalog NO. | BPG-0854 |
| Product Name | Azido-PEG10-Acid |
| CAS | 1644163-57-4 |
| Molecular Formula | C23H45N3O12 |
| Molecular Weight | 555.62 |
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| Description | Azido-PEG10-Acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| Synonyms | N3-PEG10-COOH; Azido-PEG10-C2-acid; N3-PEG10-CH2CH2COOH; Propanoic acid, 3-[(29-azido-3,6,9,12,15,18,21,24,27-nonaoxanonacos-1-yl)oxy]-; 1-Azido-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oic acid; 3,6,9,12,15,18,21,24,27,30-Decaoxatritriacontan-33-oic acid, 1-azido- |
| IUPAC Name | 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
| Canonical SMILES | C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)O |
| InChI | InChI=1S/C23H45N3O12/c24-26-25-2-4-30-6-8-32-10-12-34-14-16-36-18-20-38-22-21-37-19-17-35-15-13-33-11-9-31-7-5-29-3-1-23(27)28/h1-22H2,(H,27,28) |
| InChIKey | UOKQXCSLUSWFRF-UHFFFAOYSA-N |
| Purity | ≥95% |
| Solubility | Soluble in DMF, DMSO, Water |
| Related CAS | 1167575-20-3 (polymer) |
| Appearance | Pale Yellow Oily Matter |
| Storage | Store at 2-8°C |
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Azido-PEG10-Acid, a versatile chemical compound utilized in diverse biomedical and biotechnological contexts, offers boundless opportunities. Here are four key applications of Azido-PEG10-Acid explored through high perplexity and burstiness: Bioorthogonal Chemistry: At the forefront of bioorthogonal chemistry, Azido-PEG10-Acid emerges as a pivotal tool for labeling and tracing biomolecules within living systems. Its azide group engages in selective reactions with alkyne or cyclooctyne via click chemistry, facilitating precise attachment of probes or drugs to target molecules. This technique enables real-time visualization and analysis of intricate biological processes. Drug Delivery Systems: In the realm of advanced drug delivery systems, Azido-PEG10-Acid plays a crucial role by leveraging its polyethylene glycol (PEG) component to enhance the solubility and stability of therapeutic agents. Conjugation of drugs to Azido-PEG10-Acid enables targeted delivery to specific tissues or cells, minimizing off-target effects, and enhancing therapeutic efficacy. This approach proves particularly advantageous in precision cancer therapy and other targeted interventions. Nanotechnology: Within the dynamic field of nanotechnology, Azido-PEG10-Acid serves as a cornerstone for functionalizing nanoparticles in a myriad of biomedical applications. The PEGylation bestowed by Azido-PEG10-Acid diminishes immunogenicity and augments biocompatibility of nanoparticles, extending circulation time and bolstering targeting precision. This enhancement renders nanoparticles ideal for applications spanning imaging, diagnostics, and drug delivery. Protein Engineering: In the realm of protein engineering, Azido-PEG10-Acid emerges as an indispensable asset for site-specific protein modification. By integrating azide groups into proteins through genetic or chemical means, researchers possess the capability to affix diverse functional groups or probes to specific protein sites. This methodology facilitates in-depth exploration of protein functionality, interactions, and pathways. |
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Resources
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Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- How to Perform Polyethylene Glycol (PEG) Modification?
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
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- PEG Purification Techniques of Plasmid DNA
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- Polyethylene Glycol (PEG) Modifier Selection Guide
- Radiolabeling Technique
- SDS-PAGE Technique
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Industry News
- Applications of PEG-DSPE: Drug Carriers and Drug Delivery
- Applications of Polyethylene Glycol (PEG) as Medical Devices
- Cholesterol: Definition, Structure, Synthesis, Types and Functions
- Classification of Lipid-Based Vaccine Adjuvants
- FDA approved PEGylated Products
- FDA-Approved Antibody-Drug Conjugates up to 2024
- How are Liposomes Different from Micelles?
- How Lipid Nanoparticles (LNPs) Deliver RNA Drugs?
- Hyaluronic Acid & PEGylated Hyaluronic Acid
- Ionizable Lipids for RNA Delivery
- Lipid Classification and Drug Delivery Systems
- Lipid Formulations: Key Absorption-Enhancing Technologies in New Drug Development
- Lipid-Drug Conjugates (LDCs) for Nanoparticle Drug Delivery
- Liposome in Drug Delivery
- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
- PEG in Pharmaceutical Preparations (II): Stabilizers, Plasticizers and Modification Materials
- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated Drugs: Definition, Structure, Classification and Benefits
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Pharmacokinetics and Bioanalysis of PEGylated Drugs
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
- Vaccines: Definition, History, Ingredients, Types and Mechanism of Action
- What are Lipid Excipients and Their Applications?
- What are Lipid Nanoparticles and Their Applications?
- What are Lipid-Drug Conjugates (LDCs)?
- What are Lipids?
- What are Monodispersed and Polydispersed PEGs?
- What are PEG Lipids?
- What are Phospholipids?
- What are Sterols? - Definition, Structure, Function, Examples and Uses
- What is Biotinylation and Biotinylated PEG?
- What is Click Chemistry?
- What is Hydrogel?
- What is Methoxy Polyethylene Glycol (mPEG)?
- What is Nanogels and Its Applications?
- What is the Formulation of Lipid Nanoparticles (LNPs)?
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