2-Bromoethyl ether

Name: 2-Bromoethyl ether
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 5414-19-7

Cat No.: BPG-1798

Purity: 98 %

4.5

2-Bromoethyl ether (CAS# 5414-19-7) is used as a reagent in the synthesis of AZD 3147, a selective dual inhibitor of mTORC1 and mTORC2. Bis(2-bromoethyl) Ether is also used in the preparation of (2S)-2-Amino-3-(4-morpholin-4-ylphenyl)propanoic Acid (A618690); an impurity of Melphalan (M216900) which is an antineoplastic.

Category	Small-molecule Homobifunctional PEG
Molecular Formula	C4H8Br2O
Molecular Weight	231.91
Appearance	Colourless liquid
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Pure form, -20°C, 3 years; 4°C, 2 years; In solvent, -80°C, 6 months; -20°C, 1 month

Structure of 5414-19-7

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Specification
Key Product Attributes
Reaction & Conjugation Properties
Application

Synonyms	1-bromo-2-(2-bromoethoxy)ethane
IUPACName	1-bromo-2-(2-bromoethoxy)ethane
CanonicalSMILES	C(CBr)OCCBr
InChI	InChI=1S/C4H8Br2O/c5-1-3-7-4-2-6/h1-4H2
InChIKey	FOZVXADQAHVUSV-UHFFFAOYSA-N
BoilingPoint	92-93 °C (12 mmHg)
Purity	98 %
Density	1.845 g/cm³
ExactMass	231.89214
LogP	1.79280
Pictogram	Corrosive, Irritant
Signal	Danger
PrecautionaryStatementCodes	P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P332+P317, P362+P364, P403+P233, P405, and P501

PEGType

PEG / Oligoethylene Glycol Building Block

ReactiveToward	Nucleophiles (Amines / Thiols)
ReactionChemistry	Nucleophilic Substitution
BiomoleculeCompatibility	Amine- or Thiol-Functionalized Biomolecules
ResearchUse	Nucleophilic Linker Substitution

2-Bromoethyl ether, also known as ethylene bromide oxide, is a chemical compound with a variety of applications in the biosciences and chemical industries. Here are some key applications of 2-Bromoethyl ether:

Intermediate in Organic Synthesis: 2-Bromoethyl ether serves as an important intermediate in the synthesis of various chemical compounds. It is used in the preparation of pharmaceuticals, agrochemicals, and other organic substances. This compound's reactivity makes it valuable for forming carbon-carbon bonds and introducing bromine atoms into complex molecules.

Cross-Linking in Polymer Chemistry: In polymer chemistry, 2-Bromoethyl ether is utilized as a cross-linking agent to form three-dimensional polymer networks. It reacts with functional groups on polymer chains to create strong covalent bonds, enhancing the mechanical and thermal properties of the resulting materials. This application is especially useful in the development of high-performance plastics and resins.

Research in Biological Systems: 2-Bromoethyl ether can be employed in biological research to modify biomolecules and study their interactions. For example, it can be used to introduce bromine atoms into proteins or nucleic acids, facilitating studies on structure-function relationships. This helps in understanding biological processes and developing new biotechnological applications.

Solvent in Laboratory Settings: 2-Bromoethyl ether can be used as a solvent in various laboratory experiments due to its ability to dissolve a wide range of organic compounds. It is particularly useful in reactions that require a non-polar or weakly polar solvent. This application supports a multitude of chemical processes and reactions in research and development laboratories.