mPEG-AA, MW 5k

  • Catalog No.
  • BPG-0005
  • Product Name
  • mPEG-AA, MW 5k
  • Alias
  • mPEG-Acetic acid; mPEG-CM
  • Storage
  • -20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
  • Solubility
  • Soluble in regular aqueous solution as well as most organic solvents.
  • Description
  • mPEG-AA can be used to modify polypeptides, proteins and other materials with reactive groups. The carboxyl group can easily form a stable amide bond with an amino group, and can also form an ester bond with a hydroxyl group. Polyethylene glycol can increase solubility and stability. It also inhibits the non-specific binding of the charged molecule to the modified surface by reducing the immunogenicity of the polypeptide and protein.
  • References
  • 1. Abuchowski, Abraham, et al. Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase. Journal of Biological Chemistry, 1977, 252(11): 3582-3586.
    2. Savoca, Kenneth V., et al. Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol. Biochimica et Biophysica Acta (BBA)-Protein Structure, 1979, 578(1): 47-53.

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