Small-molecule Polyethylene Glycol

Over 4,000 high-purity PEG linkers cGMP-grade PEG products supplied Custom synthesis services supported Large inventory ensuring stable supply

ADC linker is the bridge between antibodies and cytotoxic drugs and plays a key role in antibody-drug conjugate (ADC) drugs because its properties greatly affect the therapeutic indicators, efficacy, and pharmacokinetics of these drugs. The ideal conjugation must be stable in vitro or in the blood circulation to prevent systemic toxicity caused by premature release of cytotoxic drugs, while at the same time being able to enter and kill cancer cells through the rapid release of effective cytotoxic drugs. BOC Sciences can provide ADC linkers with multiple cleavage mechanisms according to your project needs, including enzymatic cleavage linkers, chemical cleavage linkers and peptide linkers. We also support the integrated design of linkers to modulate payload release and ADC stability for optimal efficacy of ADC drugs.

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Catalog No.	Name	M.W.	Purity
In stock BPG-4837 CAS: 90335-39-0	2-(2-methoxyethoxy)ethyl benzoate	242.27	N/A
In stock BPG-4829 CAS: 10143-54-1	3-(2-(2-Hydroxyethoxy)ethoxy)propanenitrile	159.18	N/A
In stock BPG-4828 CAS: 401612-75-7	3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]propanenitrile	203.24	N/A
In stock BPG-4827 CAS: 35633-45-5	3-[2-(2-Methoxyethoxy)ethoxy]propanenitrile	173.21	N/A
In stock BPG-4826 CAS: 180316-31-8	4,7,10,13-Tetraoxatetradecane nitrile	217.26	N/A
In stock BPG-4823 CAS: 105891-50-7	({2-[2-(2-Chloroethoxy)ethoxy]ethoxy}methyl)benzene	258.74	N/A
In stock BPG-4822 CAS: 144751-75-7	BnO-PEG3-CH2COOH	298.33	N/A
In stock BPG-4821 CAS: 185022-23-5	2-(2-(2-Hydroxyethoxy)ethoxy)isoindoline-1,3-dione	251.23	N/A
In stock BPG-4818 CAS: 1415246-43-3	2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1h-isoindole-1,3(2h)-dione	295.29	N/A
In stock BPG-2620 CAS: 2243942-52-9	HO-PEG24-OH	1075.28	98%
In stock BPG-2501 CAS: 6812-36-8	HO-PEG16-OH	722.86	N/A
In stock BPG-2470 CAS: 28821-35-4	HO-PEG15-OH	678.80	98%
In stock BPG-2429 CAS: 1189112-05-7	HO-PEG14-OH	634.75	N/A
In stock BPG-2385 CAS: 17598-96-8	HO-PEG13-OH	590.699	95%
In stock BPG-2330 CAS: 6790-09-6	Dodecaethylene glycol	546.65	≥95%
In stock BPG-2266 CAS: 6809-70-7	HO-PEG11-OH	502.59	>97%
In stock BPG-2201 CAS: 5579-66-8	HO-PEG10-OH	458.54	>97%
In stock BPG-2111 CAS: 3386-18-3	HO-PEG9-OH	414.49	≥95%
In stock BPG-2041 CAS: 5117-19-1	HO-PEG8-OH	370.44	≥95%
In stock BPG-1965 CAS: 5617-32-3	HO-PEG7-OH	326.38	≥95%

Background

What is Small-molecule Polyethylene Glycol?

Small-molecule polyethylene glycol (PEG) refers to PEG compounds with low molecular weights (typically below 10,000 Da). When used as small molecules, PEGs can offer unique advantages in different fields, and can be used to modify various types of biological drugs, forming formulation materials through positively ionized lipophilic liposome nanoparticles, which will make it possible to instantly load targeted molecules and achieve mounting of any drug, and can provide proven technical support for building personalized therapeutic drug libraries for oncology patients.

Fig. 1. Structure of poly(ethylene glycol) (Theranostics. 10(7): 3064-3082).

Examples of Small Molecule Polyethylene Glycols

HO-PEG5-OH

HO-PEG5-OH is a small molecule PEG with 5 glycol units, which can be used as versatile polymer chain segments for modulating the solubility, stability, and bioavailability of drugs, or as plasticizers, lubricants, or modifiers of materials.

Hexaethylene Glycol

Hexaethylene glycol is part of jasmine leaf extract and has antioxidant, antibacterial and anticancer properties. It also shows potential application as a functional hydraulic fluid.

Dodecaethylene Glycol

Dodecaethylene glycol has a long glycol chain containing 12 glycol units. It can be used in the preparation of certain surfactants, colloidal systems and drug delivery systems, among others.

Modification of Small Molecule PEG

Depending on the nature of the reaction between the modifier and the modified compound, the modification reaction is mainly classified into the types of acylation reaction, alkylation reaction, redox reaction, aromatic ring substitution reaction, etc., which chemically modifies the modified compound with the side-chain groups such as amino group, sulfhydryl group and carboxyl group. Depending on the molecular weight, molecular structure, and physical and chemical properties of the modified compounds, including proteins, peptides, monoclonal antibody molecular fragments, and small molecule compounds, different PEGylation techniques are used to modify these compounds.

How to Activate Small Molecule PEG?

The connection between small molecule PEG and other compounds is mainly through the terminal hydroxyl group of PEG, such as amino acid residues. However, the terminal hydroxyl group of PEG is very inactive and it is difficult to couple with other groups in a mild environment, so an activator is needed to activate the hydroxyl group. Activated PEG can covalently modify the modified substance in a mild environment. Methods of activation include: cyanogen bromide method, carbonyl diimidazole method, cyanuric chloride method, and PEG structure modification method.

Application of Small Molecule PEG

Protein Precipitation: By adding appropriate amount of PEG (PEGylation of Proteins) and salt to the solution, the protein can be precipitated, thus realizing the separation and enrichment of protein.
Cell Fusion: By adding PEG to two cell populations, cells can be induced to fuse and form hybrid cells. This is useful in areas such as cell research, antibody production and bioengineering.
DNA or RNA Precipitation: By adding PEG to a DNA or RNA solution (PEGylation of Nucleic Acids), nucleic acids can be precipitated out, thereby removing impurities and purifying the target molecule.
Protein Crystallization: The use of small molecule PEGs as co-solvents can provide the right solution conditions to facilitate protein crystallization and improve the quality and growth rate of crystals.
Cell Protection and Freezing: Small molecule PEG has the ability to protect cells from damage during freezing and thawing. Mixing cells with appropriate concentrations of PEG during cell cryopreservation provides osmotic protection and reduces freezing-induced cell damage.
Stabilizers for Antibodies and Enzymes: Small molecule PEG can be used as stabilizers for antibodies and enzymes, prolonging their activity during storage and use.

BOC Sciences provides high quality small molecule PEG products based on expertise and experience, if you are interested in our products, please feel free to contact us.

Reference

Wu, D. et al. An EPR Strategy for Bio-responsive Fluorescence Guided Surgery with Simulation of the Benefit for Imaging. Theranostics. 10(7): 3064-3082.

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