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Tos-PEG4-THP

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Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-2148
Product Name	Tos-PEG4-THP
CAS	86259-89-4
Molecular Formula	C20H32O8S
Molecular Weight	432.53

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Description	Tos-PEG4-THP is a polyethylene glycol (PEG)-based PROTAC linker. Tos-PEG4-THP can be used in the synthesis of a series of PROTACs.
Synonyms	2-(2-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate; THP-PEG5-Tos; Ethanol, 2-[2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]ethoxy]-, 1-(4-methylbenzenesulfonate); 1-Tosyl-13-(tetrahydropyran-2-yl)-1,4,7,10,13-pentaoxatridecane; 1-Tosyl-13-(tetrahydro-2H-pyran-2-yl)-1,4,7,10,13-pentaoxatridecane; Ethanol, 2-[2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]ethoxy]-, 4-methylbenzenesulfonate
IUPAC Name	2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
Canonical SMILES	CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCOC2CCCCO2
InChI	InChI=1S/C20H32O8S/c1-18-5-7-19(8-6-18)29(21,22)28-17-15-25-13-11-23-10-12-24-14-16-27-20-4-2-3-9-26-20/h5-8,20H,2-4,9-17H2,1H3
InChIKey	AWIUPDGEVFBSGD-UHFFFAOYSA-N
Boiling Point	553.4±50.0 °C at 760 mmHg
Purity	≥95%
Density	1.2±0.1 g/cm3
Solubility	Soluble in DMSO
Appearance	Pale Yellow Oily Liquid
Storage	Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Tos-PEG4-THP, a versatile chemical reagent, boasts extensive applications in organic synthesis and bioconjugation. Here are four key applications of Tos-PEG4-THP articulated with a high degree of perplexity and burstiness:

Drug Delivery Systems: Harnessing the power of Tos-PEG4-THP, researchers can elevate the solubility and stability of therapeutic agents. By intricately conjugating drugs with PEG chains, this reagent assumes a pivotal role in enhancing the bioavailability and half-life of medications. This technological leap results in the optimization of drug delivery mechanisms, prolonging therapeutic effects and heralding a new era of pharmaceutical progress.

Protein Modification: Within the domain of biochemistry, Tos-PEG4-THP emerges as a critical instrument for modifying proteins, thereby reshaping their properties and functionalities. By intricately grafting PEG chains onto proteins, this reagent effectively diminishes immunogenicity and fortifies the stability of proteins within the biological milieu. Such alterations prove particularly invaluable in advancing protein-based therapeutics and diagnostics, pushing the frontiers of medical exploration.

Immunoassay Development: Tos-PEG4-THP assumes a pivotal role in the evolution of bioconjugates for immunoassays. This multifaceted reagent facilitates the seamless linkage of antigens or antibodies to solid supports or detection labels, ultimately amplifying the sensitivity and specificity of assays. Such strides are paramount in sculpting dependable diagnostic tests and cutting-edge research tools within the realms of immunology and clinical laboratories, propelling innovation in medical sciences.

Biocompatible Coatings: Representing a revolutionary approach, Tos-PEG4-THP revolutionizes the creation of biocompatible coatings on medical devices and implants. Through precise surface modifications with PEG, this reagent effectively curtails protein adsorption and inhibits cell attachment, thereby mitigating immune responses and biofouling. This groundbreaking advancement is indispensable for refining the safety and efficacy of a diverse array of biomedical products, setting new benchmarks in bioengineering and medical technology.

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