t-Boc-N-amido-PEG5-acid

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Category	Small-molecule Group Protected PEG
Catalog NO.	BPG-2102
Product Name	t-Boc-N-amido-PEG5-acid
CAS	1347750-78-0
Molecular Formula	C18H35NO9
Molecular Weight	409.47

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Product Information

Description	t-Boc-N-amido-PEG5-acid is a cleavable (5-unit PEG) ADC linker, as well as a PEG- and alkyl/ether-based PROTAC linker that can be used to synthesize antibody-drug conjugates (ADCs) or PROTACs.
Synonyms	Boc-NH-PEG5-CH2CH2COOH; t-Boc-NH-amido-PEG5-COOH; Boc-NH-PEG5-COOH; t-boc-N-amido-PEG5-propionic acid; 2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azatricosan-23-oic acid; 5,8,11,14,17-Pentaoxa-2-azaeicosanedioic acid, 1-(1,1-dimethylethyl) ester; 3,8,11,14,17,20-Hexaoxa-5-azatricosan-23-oic acid, 2,2-dimethyl-4-oxo-
IUPAC Name	3-[2-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES	CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCC(=O)O
InChI	InChI=1S/C18H35NO9/c1-18(2,3)28-17(22)19-5-7-24-9-11-26-13-15-27-14-12-25-10-8-23-6-4-16(20)21/h4-15H2,1-3H3,(H,19,22)(H,20,21)
InChIKey	RVYBVZICXVYKRD-UHFFFAOYSA-N
Boiling Point	536.9±50.0°C (Predicted)
Purity	≥95%
Density	1.123±0.06 g/cm3 (Predicted)
Solubility	Soluble in DMSO
Related CAS	187848-68-6 (polymer)
Appearance	Pale Yellow Oily Liquid
Storage	Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Exact Mass	409.23118169
LogP	1.45970

t-Boc-N-amido-PEG5-acid, a versatile chemical compound, finds frequent use in the realms of bioconjugation and drug delivery. Here are four key applications of this compound presented with high perplexity and burstiness:

Drug Delivery Systems: t-Boc-N-amido-PEG5-acid plays a pivotal role in the realm of advanced drug delivery systems. By attaching this compound to therapeutic agents, researchers can enhance the solubility, stability, and bioavailability of drugs. This modification not only facilitates targeted delivery but also enables controlled release of medications, ultimately boosting their therapeutic effectiveness.

Peptide Synthesis: Within the domain of peptide synthesis, t-Boc-N-amido-PEG5-acid emerges as an invaluable linker. It enables the conjugation of peptides to diverse carriers or surfaces while safeguarding the amine group during synthesis. This capability streamlines the creation of multifunctional peptides for applications in both research and therapeutics, expanding the possibilities for innovative peptide-based interventions.

Diagnostic Imaging: The utility of t-Boc-N-amido-PEG5-acid extends to the realm of diagnostic imaging agent development. By conjugating imaging probes, such as fluorescent dyes or radiolabels, to this compound, researchers can craft targeted imaging agents that bind specifically to cellular or molecular targets. This facilitates the visual tracking of biological processes in vivo, providing valuable insights for diagnostic purposes and therapeutic monitoring.

Surface Modification: In the landscape of biomaterials research, t-Boc-N-amido-PEG5-acid serves as a catalyst for surface modification of medical devices and implants. Coating surfaces with this compound enables the reduction of protein adsorption and enhancement of biocompatibility. This application holds particular significance in mitigating unwanted immune responses and elevating the performance of implanted devices.

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