SPDP-PEG8-COOH

Name: SPDP-PEG8-COOH
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 1334177-96-6

Cat No.: BPG-3491

Purity: ≥95%

4.5

SPDP-PEG8-COOH is a PEG-based PROTAC linker which is applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. It contains SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward amine and thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of activators such as EDC and DCC to form stable amide bonds. The water solubility properties of PEG linkers is enhanced by longer PEG chains.

Category	SPDP-PEGn-COOH
Molecular Formula	C27H46N2O11S2
Molecular Weight	638.79
Appearance	Light Yellow or White Solid
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Structure of 1334177-96-6

Ordering Information

*For research and manufacturing use only. We do not sell to patients.

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Specification

Synonyms	SPDP-PEG8-acid; OPSS-PEG8-COOH; 3-oxo-1-(pyridin-2-yldisulfanyl)-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid; alpha-[3-(o-Pyridyldisulfido)propanoylamido]-omega-carboxy octa(ethylene glycol)
IUPACName	3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
CanonicalSMILES	C1=CC=NC(=C1)SSCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O
InChI	InChI=1S/C27H46N2O11S2/c30-25(5-24-41-42-26-3-1-2-6-29-26)28-7-9-34-11-13-36-15-17-38-19-21-40-23-22-39-20-18-37-16-14-35-12-10-33-8-4-27(31)32/h1-3,6H,4-5,7-24H2,(H,28,30)(H,31,32)
InChIKey	DKWMKNTUPXBDLZ-UHFFFAOYSA-N
BoilingPoint	768.5±60.0 °C at 760 mmHg
Purity	≥95%
Density	1.2±0.1 g/cm3
Solubility	Soluble in DMSO