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SPDP-PEG5-COOH

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Category	SPDP-PEGn-COOH
Catalog NO.	BPG-3494
Product Name	SPDP-PEG5-COOH
Molecular Formula	C21H34N2O8S2
Molecular Weight	506.63

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Description	SPDP-PEG5-COOH is a PEG-based PROTAC linker which is applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. It contains SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward amine and thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of activators such as EDC and DCC to form stable amide bonds. The water solubility properties of PEG linkers is enhanced by longer PEG chains.
Synonyms	SPDP-PEG5-acid; OPSS-PEG5-COOH; 3-oxo-1-(pyridin-2-yldisulfaneyl)-7,10,13,16,19-pentaoxa-4-azadocosan-22-oic acid
IUPAC Name	3-[2-[2-[2-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES	O=C(O)CCOCCOCCOCCOCCOCCNC(CCSSC1=NC=CC=C1)=O
InChI	InChI=1S/C21H34N2O8S2/c24-19(5-18-32-33-20-3-1-2-6-23-20)22-7-9-28-11-13-30-15-17-31-16-14-29-12-10-27-8-4-21(25)26/h1-3,6H,4-5,7-18H2,(H,22,24)(H,25,26)
InChIKey	SKJJIWRMEIYIMB-UHFFFAOYSA-N
Boiling Point	699.8±55.0 °C at 760 mmHg
Purity	≥95%
Density	1.3±0.1 g/cm3
Appearance	Light Yellow or White Solid
Storage	Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

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