SPDP-PEG4-NHS ester

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Category	SPDP-PEGn-NHS ester
Catalog NO.	BPG-3503
Product Name	SPDP-PEG4-NHS ester
CAS	1334177-95-5
Molecular Formula	C23H33N3O9S2
Molecular Weight	559.65

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Description	SPDP-PEG4-NHS ester is a PEG-based PROTAC linker that has an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers.
Synonyms	SPDP-dpeg(R)4-NHS ester; 2,5-Dioxo-1-pyrrolidinyl 17-oxo-19-(2-pyridinyldithio)-4,7,10,13-tetraoxa-16-azanonadecanoate; Opss-peg(4)-nhs; N-[3-(o-Pyridyldisulfido)propanoyl]-15-amino-4,7,10,13-tetraoxa-pentadecanoyl succinimidyl ester; NHS-PEG4-SDPD; 2,5-dioxopyrrolidin-1-yl 3-oxo-1-(pyridin-2-yldisulfanyl)-7,10,13,16-tetraoxa-4-azanonadecan-19-oate
IUPAC Name	(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES	C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCNC(=O)CCSSC2=CC=CC=N2
InChI	InChI=1S/C23H33N3O9S2/c27-19(7-18-36-37-20-3-1-2-8-25-20)24-9-11-32-13-15-34-17-16-33-14-12-31-10-6-23(30)35-26-21(28)4-5-22(26)29/h1-3,8H,4-7,9-18H2,(H,24,27)
InChIKey	QTVBGVZVUCIFAH-UHFFFAOYSA-N
Purity	≥95%
Density	1.3±0.1 g/cm3
Appearance	Red Solid
Storage	Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

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