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SPDP-PEG12-NHS ester

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Category	SPDP-PEGn-NHS ester
Catalog NO.	BPG-3497
Product Name	SPDP-PEG12-NHS ester
CAS	2601437-72-1
Molecular Formula	C39H65N3O17S2
Molecular Weight	912.07

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Description	SPDP-PEG12-NHS ester is a PEG-based PROTAC linker that has an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers.
Synonyms	SPDP-dPEG(R)12-NHS ester; Opss-peg(12)-nhs; alpha-[3-(o-Pyridyldisulfido)propanoylamido]-omega-succinimidyl ester dodeca(ethylene glycol); 2,5-dioxopyrrolidin-1-yl 2-((2-(3-(pyridin-2-yldisulfaneyl)propanamido)ethoxy)methyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontanoate
IUPAC Name	(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES	C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCSSC2=CC=CC=N2
InChI	InChI=1S/C39H65N3O17S2/c43-35(7-34-60-61-36-3-1-2-8-41-36)40-9-11-48-13-15-50-17-19-52-21-23-54-25-27-56-29-31-58-33-32-57-30-28-55-26-24-53-22-20-51-18-16-49-14-12-47-10-6-39(46)59-42-37(44)4-5-38(42)45/h1-3,8H,4-7,9-34H2,(H,40,43)
InChIKey	PQUMQQHUIZYDPW-UHFFFAOYSA-N
Purity	≥95%
Density	1.3±0.1 g/cm3
Related CAS	924280-65-9
Appearance	Colorless Oily Matter
Storage	Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

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