Sodium cholesteryl sulfate

Name: Sodium cholesteryl sulfate
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 2864-50-8

Cat No.: BPG-3293

Purity: >99%

4.5

Sodium cholesteryl sulfate is an endogenous sterol sulfate and a component of cell membranes. It is an orally available, NPC2-targeted cholesterol biosynthesis agonist that activates SREBP2 by competitively binding to NPC2, promoting cholesterol synthesis (EC₅₀ = 50 μM). The compound exhibits anti-inflammatory properties, alleviating ulcerative colitis in mouse models by repairing the intestinal mucosal barrier and inhibiting inflammation through regulation of serine protease activity and PKCη signaling. It also enhances the self-assembly ability of mitoxantrone hydrochloride for antitumor activity via nano-delivery systems. Additionally, sodium cholesteryl sulfate supports platelet adhesion, regulates selective protein kinase C isoforms, and modulates PI3K specificity in keratinocyte differentiation. As a pharmaceutical excipient, it functions as an emulsifier, surfactant, and stabilizer in lipid-based formulations, helping to form and stabilize emulsions, liposomes, and colloidal drug delivery systems.

Category	Natural Sterols
Molecular Formula	C27H45NaO4S
Molecular Weight	488.70
Appearance	White to Off-white Solid
Storage	Store at -20 °C

Structure of 2864-50-8

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Specification
References

Synonyms	Cholesteryl sodium sulfate; Cholesterol 3-sulfate sodium salt; 5-Cholesten-3beta-ol sulfate sodium salt
IUPACName	sodium;[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] sulfate
CanonicalSMILES	CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OS(=O)(=O)[O-])C)C.[Na+]
InChI	InChI=1S/C27H46O4S.Na/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(31-32(28,29)30)13-15-26(20,4)25(22)14-16-27(23,24)5;/h9,18-19,21-25H,6-8,10-17H2,1-5H3,(H,28,29,30);/q;+1/p-1/t19-,21+,22+,23-,24+,25+,26+,27-;/m1./s1
InChIKey	LMPVQXVJTZWENW-KPNWGBFJSA-M
MeltingPoint	>166 °C (dec.)
Purity	>99%
Solubility	Soluble in Methanol
RelatedCAS	1256-86-6 (free acid)
ShelfLife	1 Year
ExactMass	488.294
Hygroscopic	No
LightSensitive	No
PercentComposition	C 66.36%, H 9.28%, Na 4.70%, O 13.10%, S 6.56%