Pyridin-2-yldisulfanyl-PEG4-NHS

Name: Pyridin-2-yldisulfanyl-PEG4-NHS
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 1305053-43-3

Cat No.: BPG-3605

Purity: ≥98%

4.5

Pyridin-2-yldisulfanyl-PEG4-NHS is a disulfide-containing crosslinker or linker building block for redox-responsive bioconjugation and ADC-related linker design. The disulfide bond provides a reduction-sensitive element, while the terminal reactive groups enable attachment to appropriately functionalized biomolecules or small-molecule partners. The molecule uses no dedicated antibody-reactive group unless activated/functionalized; terminal functionality depends on the specific peg derivative on one side and pyridyl-disulfide / activated disulfide handle for thiol-containing payloads or thiol exchange partners on the other, with peg4 spacer providing the spacer/cleavable region. Conjugation orientation and reduction sensitivity should be evaluated in the context of the final construct because local substitution and neighboring groups can influence disulfide behavior.

Category	SPDP-PEGn-NHS ester
Molecular Formula	C20H28N2O8S2
Molecular Weight	488.57
Appearance	Colorless to Light Yellow Viscous Liquid
Shipping	Room temperature
Storage	Store at 2-8°C

Structure of 1305053-43-3

Ordering Information

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Specification

Synonyms	PEG4-SPDP; 15-(2-pyridyldithio)-4,7,10,13-tetraoxapentadecanoic acid N-hydroxysuccinimide ester; (2-pyridyldithio)-PEG4-NHS ester; 2,5-dioxopyrrolidin-1-yl 1-(pyridin-2-yldisulfaneyl)-3,6,9,12-tetraoxapentadecan-15-oate; 2,5-dioxo-1-pyrrolidinyl 15-(2-Pyridinyldithio)-4,7,10,13-tetraoxapentadecanoate; 1-{[15-(2-Pyridinyldisulfanyl)-4,7,10,13-tetraoxapentadecan-1-oyl]oxy}-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[[1-oxo-15-(2-pyridinyldithio)-4,7,10,13-tetraoxapentadec-1-yl]oxy]-; 4,7,10,13-Tetraoxapentadecanoic acid, 15-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester
IUPACName	(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(pyridin-2-yldisulfanyl)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
CanonicalSMILES	C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCSSC2=CC=CC=N2
InChI	InChI=1S/C20H28N2O8S2/c23-18-4-5-19(24)22(18)30-20(25)6-8-26-9-10-27-11-12-28-13-14-29-15-16-31-32-17-3-1-2-7-21-17/h1-3,7H,4-6,8-16H2
InChIKey	AZXJOPLHLVNPKQ-UHFFFAOYSA-N
BoilingPoint	605.9±65.0°C at 760 mmHg
Purity	≥98%
Density	1.3±0.1 g/cm3
Solubility	Soluble in DMSO