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DBCO-PEG4-NHS ester

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Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-2441
Product Name	DBCO-PEG4-NHS ester
CAS	1427004-19-0
Molecular Formula	C34H39N3O10
Molecular Weight	649.69

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Catalog Number	Size	Price	Stock	Quantity
BPG-2441	100 mg	$838	In stock

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Description	DBCO-PEG4-NHS ester is PEG derivative used as a cross-linker to react with primary amines.
Synonyms	Azadibenzocyclooctyne-PEG4-NHS ester
IUPAC Name	(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES	C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCNC(=O)CCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42
InChI	InChI=1S/C34H39N3O10/c38-30(11-12-31(39)36-25-28-7-2-1-5-26(28)9-10-27-6-3-4-8-29(27)36)35-16-18-44-20-22-46-24-23-45-21-19-43-17-15-34(42)47-37-32(40)13-14-33(37)41/h1-8H,11-25H2,(H,35,38)
InChIKey	RRCXYKNJTKJNTD-UHFFFAOYSA-N
Purity	>95%
Density	1.3±0.1 g/cm3
Solubility	In DMSO: 83.33 mg/mL (128.26 mM; Need ultrasonic)
Appearance	Transparent Liquid
Storage	4°C, stored under nitrogen; In solvent, -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Exact Mass	649.26354445

DBCO-PEG4-NHS ester, a versatile chemical reagent widely utilized in bioconjugation techniques, finds diverse applications. Explore four key applications below, presented with a high degree of perplexity and burstiness:

Antibody-Drug Conjugates: Play at the intersection of science and medicine, where DBCO-PEG4-NHS ester serves as the linchpin for conjugating therapeutic antibodies with cytotoxic drugs, giving birth to potent antibody-drug conjugates (ADCs). This innovative approach enables precise drug delivery to specific cancer cells, amplifying treatment efficacy while minimizing collateral damage. The incorporation of a PEG4 linker ensures the structural integrity and solubility of the conjugate in complex biological milieus.

Protein Labeling: Step into the realm of proteomics with DBCO-PEG4-NHS ester, a cornerstone in labeling proteins with an array of tags, from fluorescent dyes to biotin, for detection and imaging purposes. By engaging with primary amines on the protein surface, this reagent facilitates robust and enduring covalent attachment, underpinning critical research in proteomics and diagnostic assays. Embrace the power of precision in visualizing the intricacies of biological molecules, driving cutting-edge advancements in protein studies.

Cell Surface Modification: Witness the transformation of cell biology with DBCO-PEG4-NHS ester, a catalyst for modifying cell surfaces for tracking and targeting endeavors. This versatile reagent empowers the attachment of ligands or markers to cell membrane proteins without compromising cellular vitality, promising breakthroughs in cell biology investigations and the evolution of cell-based therapies. Embark on a journey of discovery where every modification opens up new possibilities in cellular research and therapeutic development.

Click Chemistry: Immerse yourself in the world of bioorthogonal chemistry with DBCO-PEG4-NHS ester, the cornerstone of rapid and precise bioconjugation reactions. By selectively reacting with azide groups to forge stable triazole linkages, this reagent enables the synthesis of intricate biomolecules, from multifunctional nanoparticles to cutting-edge in vivo imaging agents. Embrace the limitless potential of click chemistry in crafting sophisticated tools for biomedical research and imaging applications, pushing the boundaries of scientific exploration.

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