Propargyl-PEG4-tos

Name: Propargyl-PEG4-tos
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 875770-32-4

Cat No.: BPG-2065

Purity: >98.0%

4.5

Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category	Small-molecule Heterobifunctional PEG
Molecular Formula	C18H26O7S
Molecular Weight	386.46
Appearance	Solid
Shipping	Room temperature
Storage	Store at -20 °C, keep in dry and avoid sunlight.

Structure of 875770-32-4

Ordering Information

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Specification
Key Product Attributes
Reaction & Conjugation Properties

Synonyms	Propargyl-PEG5-Tos; 3,6,9,12-Tetraoxapentadec-14-yn-1-yl 4-methylbenzenesulfonate
IUPACName	2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
CanonicalSMILES	CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCOCC#C
InChI	InChI=1S/C18H26O7S/c1-3-8-21-9-10-22-11-12-23-13-14-24-15-16-25-26(19,20)18-6-4-17(2)5-7-18/h1,4-7H,8-16H2,2H3
InChIKey	VUJIUZITHCTEAF-UHFFFAOYSA-N
BoilingPoint	498.1±45.0 °C at 760 mmHg
FlashPoint	255.0±28.7 °C
Purity	>98.0%
Density	1.2±0.1 g/cm3
Solubility	10 mm in DMSO
ShelfLife	0-4°C for short term (days to weeks), or -20°C for long term (months).
VaporPressure	0.0±1.2 mmHg at 25°C
LogP	0.78

PEGType	Discrete PEG Linker
PEGArchitecture	Linear
Functionality	Heterobifunctional

ReactiveToward	Azides; Nucleophiles (Amines / Thiols)
ReactionChemistry	CuAAC Click Chemistry; Nucleophilic Substitution
BiomoleculeCompatibility	Click-Handle-Modified Proteins / Peptides; Click-Handle-Modified Antibodies; Click-Handle-Modified Oligonucleotides; Small Molecules / Probes; Amine- or Thiol-Functionalized Biomolecules
ResearchUse	Copper-Catalyzed Azide–Alkyne Ligation; Nucleophilic Linker Substitution