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Propargyl-PEG4-thiol

CAS No. CAS No.: 1347750-80-4
Cat No. Cat No.: BPG-1829
Purity Purity: >98.0%
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Propargyl-PEG4-thiol is an alkyne-functionalized ADC linker with a terminal thiol for maleimide or disulfide chemistry. It enables flexible bioconjugation in antibody-drug conjugates, offering enhanced solubility, spacer length, and reduced steric hindrance.

Category Small-molecule Heterobifunctional PEG
Molecular Formula C11H20O4S
Molecular Weight 248.34
Appearance Colorless Liquid
Shipping Room temperature
Storage Store at -20 °C, keep in dry and avoid sunlight.
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Propargyl-PEG4-thiol

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  • Specification
Synonyms Alkyne-PEG4-thiol;Propyne-PEG4-SH; 3,6,9,12-Tetraoxapentadec-14-yne-1-thiol
IUPACName 2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethanethiol
CanonicalSMILES C#CCOCCOCCOCCOCCS
InChI InChI=1S/C11H20O4S/c1-2-3-12-4-5-13-6-7-14-8-9-15-10-11-16/h1,16H,3-11H2
InChIKey QFVYBCQBSOIWFU-UHFFFAOYSA-N
BoilingPoint 332.9±37.0 °C at 760 mmHg
FlashPoint 155.1±26.5 °C
Purity >98.0%
Density 1.1±0.1 g/cm3
Solubility 10 mm in DMSO
ShelfLife 0-4°C for short term (days to weeks), or -20°C for long term (months).
VaporPressure 0.0±0.7 mmHg at 25°C
LogP 0.09

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