Propargyl-O-C1-amido-PEG3-C2-NHS ester

Name: Propargyl-O-C1-amido-PEG3-C2-NHS ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 2101206-78-2

Cat No.: BPG-3607

Purity: 98%

4.5

Propargyl-O-C1-amido-PEG3-C2-NHS ester is a PEG-containing bioorthogonal conjugation building block that provides an alkyne handle for modular click-chemistry workflows. The molecule can be used to introduce a click-reactive group onto an antibody, peptide, linker intermediate, or payload-containing component, depending on the chemistry of its second terminal functionality. Its additional reactive group is nhs/succinimidyl ester (amine-reactive) for antibody lysines/primary amines. The structure includes peg3 spacer to provide hydrophilic spacing. Conjugation can be performed using cuaac with an azide-functionalized partner; use orthogonal terminal group for the other conjugation step. The sequence and orientation of the coupling steps should be selected according to the functional groups carried by the two conjugation partners.

Category	Propargyl-O-C1-amido-PEGn-C2-NHS ester
Molecular Formula	C18H26N2O9
Molecular Weight	414.41
Appearance	Soild powder
Shipping	Room temperature
Storage	Store at 2-8°C

Structure of 2101206-78-2

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Specification

Synonyms	4,7,10,16-Tetraoxa-13-azanonadec-18-ynoic acid, 14-oxo-, 2,5-dioxo-1-pyrrolidinyl ester; N-{2-[2-(2-{3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy}ethoxy)ethoxy]ethyl}-2-(2-propyn-1-yloxy)acetamide; Acetamide, N-[2-[2-[2-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy]ethoxy]ethoxy]ethyl]-2-(2-propyn-1-yloxy)-; 2,5-Dioxopyrrolidin-1-yl 14-oxo-4,7,10,16-tetraoxa-13-azanonadec-18-yn-1-oate
IUPACName	(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[(2-prop-2-ynoxyacetyl)amino]ethoxy]ethoxy]ethoxy]propanoate
CanonicalSMILES	C#CCOCC(=O)NCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O
InChI	InChI=1S/C18H26N2O9/c1-2-7-28-14-15(21)19-6-9-26-11-13-27-12-10-25-8-5-18(24)29-20-16(22)3-4-17(20)23/h1H,3-14H2,(H,19,21)
InChIKey	ODGFZGOFEXLWHL-UHFFFAOYSA-N
Purity	98%
Density	1.3±0.1 g/cm3
Solubility	Soluble in DMSO