mPEG9-alcohol

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Category	Small-molecule Methoxy Linear PEG (mPEG)
Catalog NO.	BPG-2137
Product Name	mPEG9-alcohol
CAS	6048-68-6
Molecular Formula	C19H40O10
Molecular Weight	428.51

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Description	Nonaethylene glycol monomethyl ether is a polyethylene glycol (PEG)-based PROTAC linker. Nonaethylene glycol monomethyl ether can be used in the synthesis of a series of PROTACs.
Synonyms	Nonaethylene glycol monomethyl ether; 2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-ol; mPEG9-OH
IUPAC Name	2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES	COCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChI	InChI=1S/C19H40O10/c1-21-4-5-23-8-9-25-12-13-27-16-17-29-19-18-28-15-14-26-11-10-24-7-6-22-3-2-20/h20H,2-19H2,1H3
InChIKey	VVHAVLIDQNWEKF-UHFFFAOYSA-N
Boiling Point	490.1±40.0 °C at 760 mmHg
Purity	>98%
Density	1.10
Appearance	Colorless Liquid
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

mPEG9-alcohol is a polyethylene glycol derivative used in various biological and pharmaceutical applications. Here are some key applications of mPEG9-alcohol:

Drug Delivery Systems: mPEG9-alcohol is used to enhance the solubility and stability of therapeutic compounds in drug delivery systems. By attaching mPEG9-alcohol to drugs, pharmaceutical scientists can improve the bioavailability and reduce the immunogenicity of the drugs. This results in more effective and longer-lasting medications.

Protein Modification: In biopharmaceuticals, mPEG9-alcohol is used to modify proteins to improve their pharmacokinetic and pharmacodynamic properties. PEGylation, the process of attaching PEG molecules like mPEG9-alcohol to proteins, helps in reducing protein degradation and increasing circulatory half-life. This technique is widely used to enhance the efficacy of protein-based therapies.

Surface Coatings: mPEG9-alcohol can be used to create biocompatible surface coatings for medical devices. By coating surfaces with mPEG9-alcohol, it is possible to reduce protein adsorption and cell adhesion, minimizing the risk of biofouling and infection. This application is critical for improving the longevity and safety of implants and other medical devices.

Bioconjugation: mPEG9-alcohol is employed in bioconjugation techniques to attach biologically active molecules to various substrates. It acts as a linker to conjugate enzymes, antibodies, or other bioactive agents to nanoparticles, beads, or surfaces. This facilitates targeted delivery, enhanced detection, and improved outcomes in both diagnostic and therapeutic applications.

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