mPEG9-alcohol
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| Category | Small-molecule Methoxy Linear PEG (mPEG) |
| Catalog NO. | BPG-2137 |
| Product Name | mPEG9-alcohol |
| CAS | 6048-68-6 |
| Molecular Formula | C19H40O10 |
| Molecular Weight | 428.51 |
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| Description | Nonaethylene glycol monomethyl ether is a polyethylene glycol (PEG)-based PROTAC linker. Nonaethylene glycol monomethyl ether can be used in the synthesis of a series of PROTACs. |
| Synonyms | Nonaethylene glycol monomethyl ether; 2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-ol; mPEG9-OH |
| IUPAC Name | 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol |
| Canonical SMILES | COCCOCCOCCOCCOCCOCCOCCOCCOCCO |
| InChI | InChI=1S/C19H40O10/c1-21-4-5-23-8-9-25-12-13-27-16-17-29-19-18-28-15-14-26-11-10-24-7-6-22-3-2-20/h20H,2-19H2,1H3 |
| InChIKey | VVHAVLIDQNWEKF-UHFFFAOYSA-N |
| Boiling Point | 490.1±40.0 °C at 760 mmHg |
| Purity | >98% |
| Density | 1.10 |
| Appearance | Colorless Liquid |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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mPEG9-alcohol is a polyethylene glycol derivative used in various biological and pharmaceutical applications. Here are some key applications of mPEG9-alcohol: Drug Delivery Systems: mPEG9-alcohol is used to enhance the solubility and stability of therapeutic compounds in drug delivery systems. By attaching mPEG9-alcohol to drugs, pharmaceutical scientists can improve the bioavailability and reduce the immunogenicity of the drugs. This results in more effective and longer-lasting medications. Protein Modification: In biopharmaceuticals, mPEG9-alcohol is used to modify proteins to improve their pharmacokinetic and pharmacodynamic properties. PEGylation, the process of attaching PEG molecules like mPEG9-alcohol to proteins, helps in reducing protein degradation and increasing circulatory half-life. This technique is widely used to enhance the efficacy of protein-based therapies. Surface Coatings: mPEG9-alcohol can be used to create biocompatible surface coatings for medical devices. By coating surfaces with mPEG9-alcohol, it is possible to reduce protein adsorption and cell adhesion, minimizing the risk of biofouling and infection. This application is critical for improving the longevity and safety of implants and other medical devices. Bioconjugation: mPEG9-alcohol is employed in bioconjugation techniques to attach biologically active molecules to various substrates. It acts as a linker to conjugate enzymes, antibodies, or other bioactive agents to nanoparticles, beads, or surfaces. This facilitates targeted delivery, enhanced detection, and improved outcomes in both diagnostic and therapeutic applications. |
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Industry News
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