Methyltetrazine-amido-N-bis(PEG4-NHS ester)

Name: Methyltetrazine-amido-N-bis(PEG4-NHS ester)
Brand: BOC Sciences
Rating: 5 (1 reviews)

Cat No.: BPG-4744

Purity: 0.98

4.5

Methyltetrazine-amido-N-bis(PEG4-NHS ester) is a click chemistry PEG reagent which contains two NHS ester groups and a methyltetrazine group. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The NHS esters can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG linker increases the water solubility properties of the compound. Please contact us for GMP-grade inquiries.

Category	PEG-X-PEG
Molecular Formula	C41H57N7O17
Molecular Weight	919.9
Shipping	Ambient temperature
Storage	-20°C

Structure of Methyltetrazine-amido-N-bis(PEG4-NHS ester)

Ordering Information

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Specification
Key Product Attributes
Reaction & Conjugation Properties

Synonyms	BP-25417; Methyltetrazine-amido-N-bis(PEG4-NHS ester)
IUPACName	(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethyl-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]acetyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
CanonicalSMILES	CC1=NN=C(N=N1)C2=CC=C(C=C2)CC(=O)N(CCOCCOCCOCCOCCC(=O)ON3C(=O)CCC3=O)CCOCCOCCOCCOCCC(=O)ON4C(=O)CCC4=O
InChI	InChI=1S/C41H57N7O17/c1-31-42-44-41(45-43-31)33-4-2-32(3-5-33)30-38(53)46(12-16-58-20-24-62-28-26-60-22-18-56-14-10-39(54)64-47-34(49)6-7-35(47)50)13-17-59-21-25-63-29-27-61-23-19-57-15-11-40(55)65-48-36(51)8-9-37(48)52/h2-5H,6-30H2,1H3
InChIKey	VHYRRYKYSXBXQI-UHFFFAOYSA-N
Purity	0.98

PEGType	Multi-Arm PEG
PEGArchitecture	2-Arm Branched
Functionality	Heterobifunctional

ReactiveToward	TCO / Strained Alkenes; Primary Amines
ReactionChemistry	IEDDA Click Chemistry; Activated-Ester Amine Coupling
BiomoleculeCompatibility	Click-Handle-Modified Proteins / Peptides; Click-Handle-Modified Antibodies; Click-Handle-Modified Oligonucleotides; Small Molecules / Probes; Proteins / Antibodies; Peptides; Amine-Modified Oligonucleotides
ResearchUse	Tetrazine–TCO Ligation; Amine-Selective Biomolecule Coupling; Multivalent Hydrogel / Polymer Crosslinking