Mal-amido-PEG8-acid

Name: Mal-amido-PEG8-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 1334177-86-4

Cat No.: BPG-2386

Purity: >97%

4.5

Mal-amido-PEG8-acid is a PEG derivative containing a maleimide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Category	Small-molecule Heterobifunctional PEG
Molecular Formula	C26H44N2O13
Molecular Weight	592.63
Appearance	Solid powder
Shipping	-20°C (International: -20°C)
Storage	Store at -18°C

Structure of 1334177-86-4

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Specification
Key Product Attributes
Reaction & Conjugation Properties

Synonyms	Mal-amido-PEG8-C2-acid; 3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
IUPACName	3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
CanonicalSMILES	C1=CC(=O)N(C1=O)CCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O
InChI	InChI=1S/C26H44N2O13/c29-23(3-6-28-24(30)1-2-25(28)31)27-5-8-35-10-12-37-14-16-39-18-20-41-22-21-40-19-17-38-15-13-36-11-9-34-7-4-26(32)33/h1-2H,3-22H2,(H,27,29)(H,32,33)
InChIKey	ARKUDJPBDMAVBL-UHFFFAOYSA-N
Purity	>97%
ExactMass	592.28433946
LogP	-0.64600

PEGType	Discrete PEG Linker
PEGArchitecture	Linear
Functionality	Heterobifunctional

ReactiveToward	Thiols; Primary Amines (after activation)
ReactionChemistry	Maleimide-Thiol Conjugation; Carbodiimide-Mediated Amide Coupling (EDC/NHS)
BiomoleculeCompatibility	Thiol-Bearing Proteins / Antibodies; Cysteine-Containing Peptides; Thiol-Modified Oligonucleotides; Proteins / Antibodies; Peptides; Amine-Modified Oligonucleotides
ResearchUse	Thiol-Selective Biomolecule Conjugation; Carboxyl-to-Amine Coupling after Activation; Amide Bond Formation