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Hydroxy-PEG4-t-butyl ester

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Category Small-molecule Group Protected PEG
Catalog NO. BPG-1956
Product Name Hydroxy-PEG4-t-butyl ester
CAS 518044-32-1
Molecular Formula C15H30O7
Molecular Weight 322.39
Hydroxy-PEG4-t-butyl ester
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Product Information

Description Hydroxy-PEG4-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 191).
Synonyms HO-PEG4-CH2CH2COOtBu; Hydroxy-PEG4-(CH2)2-Boc; OH-PEG4-TBA; OH-PEG4-CH2CH2COOtBu; HO-PEG4-t-butyl ester; tert-Butyl 1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate; 15-Hydroxy-4,7,10,13-tetraoxapentadecanoic acid tert-butyl ester; 2-Methyl-2-propanyl 1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate; 3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-hydroxy-, 1,1-dimethylethyl ester
IUPAC Name tert-butyl 3-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES CC(C)(C)OC(=O)CCOCCOCCOCCOCCO
InChI InChI=1S/C15H30O7/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h16H,4-13H2,1-3H3
InChIKey FJRDXEGYAVAMLB-UHFFFAOYSA-N
Boiling Point 406.8±35.0 °C at 760 mmHg
Purity ≥95%
Density 1.047±0.1 g/cm3
Solubility Soluble in DCM, DMSO, Water
Related CAS 1186025-29-5 (polymer) 892154-71-1 (polymer)
Appearance Colorless to light yellow to light orange clear liquid
Storage Store at 2-8°C
Exact Mass 322.19915329
LogP 0.77690
Pictogram(s) Irritant
Signal Warning
Precautionary Statement Codes P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

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