DSG-PEG 2000

Name: DSG-PEG 2000
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 308805-39-2

Cat No.: BPG-2980

Purity: 98%

4.5

DSG-PEG 2000 is a non-ionic PEGylated lipid widely used as a steric-stabilizing excipient in lipid-based formulations. It consists of a hydrophobic distearoyl-rac-glycerol anchor covalently linked to a hydrophilic polyethylene glycol (PEG 2000) chain, enabling the DSG moiety to embed in the lipid bilayer while the PEG segment extends outward to form a hydrated, neutral surface layer. This structure minimizes non-specific interactions, enhances colloidal stability, and supports prolonged circulation. DSG-PEG 2000 is used in lipid nanoparticle (LNP) and liposome preparation for siRNA, mRNA, DNA, and small molecule delivery. Notably, DSG-PEG dissociates more slowly from LNPs than DMG-PEG due to its longer C18 alkyl chains, resulting in longer circulation times. It has been employed in GalNAc-LNP formulations for CRISPR base editing delivery, where the DSG anchor showed considerably higher potency than cholesterol or C20 anchors.

Category	Functionalized PEG Lipids
Molecular Formula	(C2H4O)nC40H78O5
Appearance	Powder
Storage	Store at -20 °C

Structure of 308805-39-2

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Specification
References

Synonyms	distearoyl-rac-glycerol-PEG2K; distearoyl-rac-glycerol-3-methoxypolyethylene glycol-2000; Poly(oxy-1,2-ethanediyl), α-[2,3-bis[(1-oxooctadecyl)oxy]propyl]-ω-methoxy-; α-[2,3-Bis[(1-oxooctadecyl)oxy]propyl]-ω-methoxypoly(oxy-1,2-ethanediyl); 1,2-distearoyl-glycero-3-methoxypolyethylene glycol-2000; 1,2-Distearoyl-rac-glycero-3-methylpolyoxyethylene; Distearoylglycerol-polyethylene glycol; DSG-mPEG; DSG-PEG; Sunbright DSG 2H
Purity	98%
RelatedCAS	1024639-15-3 (Deleted CAS) 1792974-95-8 (Deleted CAS)
ShelfLife	1 Year
ExactMass	2619.76
Hygroscopic	No
LightSensitive	No
PercentComposition	C 59.56% H 9.92% O 30.52%