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DNP-PEG1-NHS ester

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Category DNP-PEGn-NHS ester
Catalog NO. BPG-1667
Product Name DNP-PEG1-NHS ester
Molecular Formula C15H16N4O9
Molecular Weight 396.31
DNP-PEG1-NHS ester
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Product Information

Description DNP-PEG1-NHS ester is a PEG linker containing a DNP moiety and an NHS ester terminal group. DNP is involved in biological applications such as involvement in ion transport across membranes. The NHS ester can react with primary amines to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Synonyms 2,5-dioxopyrrolidin-1-yl 3-(2-((2,4-dinitrophenyl)amino)ethoxy)propanoate
IUPAC Name (2,5-dioxopyrrolidin-1-yl) 3-[2-(2,4-dinitroanilino)ethoxy]propanoate
Canonical SMILES C1CC(=O)N(C1=O)OC(=O)CCOCCNC2=C(C=C(C=C2)[N+](=O)[O-])[N+](=O)[O-]
InChI InChI=1S/C15H16N4O9/c20-13-3-4-14(21)17(13)28-15(22)5-7-27-8-6-16-11-2-1-10(18(23)24)9-12(11)19(25)26/h1-2,9,16H,3-8H2
InChIKey KWTXZNHZKRYFJL-UHFFFAOYSA-N
Purity ≥95%
Related CAS 1334178-01-6 (polymer)
Appearance Pale Yellow or Colorless Oily Matter
Storage Store at 2-8°C

DNP-PEG1-NHS ester, a versatile compound crucial in bioconjugation and labeling endeavors, finds diverse applications presented with a high degree of perplexity and burstiness.

Protein Labeling: Serving as a pivotal tool, DNP-PEG1-NHS ester enables the labeling of proteins with a DNP moiety, enhancing discernment in various assays. The NHS ester forms enduring amide bonds with protein amines, crucial for scrutinizing protein localization, interactions, and functionalities with depth and precision.

Antibody Conjugation: In immunological exploration, DNP-PEG1-NHS ester plays a key role in crafting DNP-tagged antibodies for tailored detection and quantification probes. These antibodies amplify sensitivity and specificity in techniques like ELISA and Western blotting, adding intricate finesse to immunodetection approaches.

Drug Delivery Systems: By facilitating targeted drug delivery systems, DNP-PEG1-NHS ester revolutionizes therapeutic approaches. The conjugation of therapeutic agents with precision-targeting entities enhances biocompatibility and efficacy, ushering in an era of more targeted therapies with reduced side effects.

Surface Modification: Acting as a cornerstone in surface alterations, DNP-PEG1-NHS ester enhances biosensors and analytical apparatuses with DNP moieties. This integration allows for the immobilization of DNP-specific antibodies, enhancing the identification of target analytes with unprecedented accuracy and reliability. Surface modification with DNP-PEG1-NHS ester elevates the functionality of diagnostic instruments to new levels.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
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