Cl-C6-PEG10-O-CH2COOH

Name: Cl-C6-PEG10-O-CH2COOH
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Cl-C6-PEGn-O-CH2COOH
Catalog NO.	BPG-1522
Product Name	Cl-C6-PEG10-O-CH2COOH
Molecular Formula	C28H55ClO13
Molecular Weight	635.19

Cl-C6-PEG10-O-CH2COOH @(data.CAS != null ? $"| CAS " : "") - BOC Sciences

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Description	Cl-C6-PEG10-O-CH2COOH is a PROTAC linker that can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).
Synonyms	39-chloro-3,6,9,12,15,18,21,24,27,30,33-undecaoxanonatriacontanoic acid
IUPAC Name	2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
SMILES	O=C(O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCCCCCCl
InChI	InChI=1S/C28H55ClO13/c29-5-3-1-2-4-6-32-7-8-33-9-10-34-11-12-35-13-14-36-15-16-37-17-18-38-19-20-39-21-22-40-23-24-41-25-26-42-27-28(30)31/h1-27H2,(H,30,31)
InChIKey	FQQBSBAFCJGGQH-UHFFFAOYSA-N
Purity	≥95%
Storage	Store at 2-8°C

Cl-C6-PEG10-O-CH2COOH, a versatile chemical compound with a wide array of applications across scientific and industrial spheres, particularly excels in bioconjugation. Here are four key applications:

Bioconjugation: Positioned as a linchpin in bioconjugation, Cl-C6-PEG10-O-CH2COOH assumes a crucial role in seamlessly linking biomolecules like antibodies, proteins, and peptides to various functional entities. Through its polyethylene glycol (PEG) spacer, this compound adeptly navigates steric hindrance while amplifying conjugate solubility. This unique attribute holds paramount importance in sculpting sophisticated diagnostic tools and precision-targeted therapeutics.

Drug Delivery Systems: The incorporation of a PEG chain within Cl-C6-PEG10-O-CH2COOH significantly elevates the pharmacokinetic properties of drug delivery systems. By tethering therapeutic agents to this compound, researchers augment drug solubility, stability, and circulation time in the bloodstream. This optimization ultimately ushers in heightened drug efficacy and diminished adverse effects, thereby fostering more efficacious treatment regimens.

Surface Modification: Cl-C6-PEG10-O-CH2COOH emerges as a potent instrument for surface modification of nanoparticles, implants, and various biomedical devices. PEGylation of surfaces effectively curtails protein adsorption and cellular adhesion, thereby mitigating immune responses and fortifying biocompatibility. This application bears particular importance in the realm of medical implants and biosensors, where seamless integration within the biological milieu hinges on impeccable biocompatibility.

Protein Purification: In the realm of protein purification protocols, Cl-C6-PEG10-O-CH2COOH finds its niche in crafting PEGylated affinity tags. These tags play a pivotal role in selectively binding and segregating target proteins from intricate mixtures. By incorporating this compound, the purification process undergoes streamlining, culminating in amplified yield and purity in the production of therapeutic proteins and enzymes.

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