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Chol-PEG600

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Category	mPEG Sterols
Catalog NO.	BPG-3003
Product Name	Chol-PEG600
CAS	27321-96-6
Molecular Formula	C55H102O15
Molecular Weight	1003.39

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Description	Chol-PEG600 is a nonionic amphipathic lipid and a cholesterol derivative. It is a water soluble, non-homogeneous compound containing hydrophobic cholesterol and covalently bound hydrophilic PEG.
Synonyms	Cholesterol-(polyethylene glycol-600)
IUPAC Name	2-[[10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethanol
Canonical SMILES	CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OCCO)C)C
InChI	InChI=1S/C29H50O2/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(31-18-17-30)13-15-28(22,4)27(24)14-16-29(25,26)5/h9,20-21,23-27,30H,6-8,10-19H2,1-5H3
InChIKey	NPYXBHZQVNRAOF-UHFFFAOYSA-N
Flash Point	210.5°C
Purity	>99%
Density	1 g/cm³
Appearance	Oil
Shelf Life	1 Year
Storage	Store at -20°C
Exact Mass	1002.72
Hygroscopic	Yes
Light Sensitive	No
Percent Composition	C 65.84%, H 10.25%, O 23.92%
Pictogram(s)	Irritant
Signal	Warning
Precautionary Statement Codes	P264, P270, P301+P317, P330, and P501

Chol-PEG600, a widely utilized cholesterol-polyethylene glycol conjugate, finds diverse applications in the realm of biomedicine. Here are four key applications of Chol-PEG600, presented with a high degree of perplexity and burstiness:

Lipid Nanoparticle Formulations: Embracing Chol-PEG600 in lipid nanoparticle formulations is a common practice in the realm of drug delivery systems. By integrating Chol-PEG600 into these nanoparticles, stability and circulation time are significantly enhanced within the bloodstream. This advancement enables targeted delivery of therapeutics, thereby amplifying treatment efficacy for challenging conditions like cancer and metabolic diseases.

Nanomedicine: Within the intricate domain of nanomedicine, Chol-PEG600 emerges as a vital component for enhancing the biocompatibility and biodistribution of nanocarriers. The inclusion of polyethylene glycol (PEG) confers a hydrophilic "stealth" layer that effectively reduces protein adsorption and immune recognition. As a result, clearance by the reticuloendothelial system is minimized, leading to prolonged nanoparticle persistence and heightened target specificity.

Vaccine Development: Chol-PEG600 assumes a pivotal role in the evolution of lipid-based vaccine carriers, particularly in the context of mRNA vaccines. Its presence stabilizes and shields the encapsulated genetic material, ensuring efficacious delivery to antigen-presenting cells. This application is instrumental in augmenting the immunogenicity and efficacy of contemporary vaccines, driving advances in the field of immunization.

Surface Modification: The utilization of Chol-PEG600 extends to the realm of surface modification for biomaterials and medical devices. Coating surfaces with Chol-PEG600 serves to mitigate protein adsorption and cell adhesion, thereby reducing foreign body reactions and enhancing overall biocompatibility. This aspect is particularly critical for enhancing the performance of implantable devices and scaffolds used in tissue engineering endeavors.

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