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CHO-Ph-CONH-PEG9-amine

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Category	CHO-Ph-CONH-PEGn-amine
Catalog NO.	BPG-0916
Product Name	CHO-Ph-CONH-PEG9-amine
Molecular Formula	C28H48N2O11
Molecular Weight	588.70

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Description	CHO-Ph-CONH-PEG9-amine is a small molecule PEG linker with a benzaldehyde moiety and a terminal amine NH2 group. The benzaldehyde can undergo reactions with primary amine groups. The primary amine can react with carboxylic acids, activated NHS esters and other carbonyl compounds. The hydrophilic PEG linker increases the water solubility of the compound in aqueous solutions.
Synonyms	Ald-Ph-PEG9-amine; Ald-Ph-amido-C2-PEG9-amine; CHO-Ph-PEG9-amine; N-(29-amino-3,6,9,12,15,18,21,24,27-nonaoxanonacosyl)-4-formylbenzamide
IUPAC Name	N-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]-4-formylbenzamide
Canonical SMILES	O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN)C1=CC=C(C=O)C=C1
InChI	InChI=1S/C28H48N2O11/c29-5-7-33-9-11-35-13-15-37-17-19-39-21-23-41-24-22-40-20-18-38-16-14-36-12-10-34-8-6-30-28(32)27-3-1-26(25-31)2-4-27/h1-4,25H,5-24,29H2,(H,30,32)
InChIKey	YMMIYYKFOVABBY-UHFFFAOYSA-N
Purity	≥95%
Storage	Store at 2-8°C

CHO-Ph-CONH-PEG9-amine is a functionalized polyethylene glycol (PEG) derivative often used in bioconjugation and drug delivery systems. Here are some key applications of CHO-Ph-CONH-PEG9-amine:

Antibody-Drug Conjugates (ADCs): CHO-Ph-CONH-PEG9-amine is used in the preparation of antibody-drug conjugates, where it serves as a linker between the cytotoxic drug and the antibody. The PEG linker improves the solubility and stability of the conjugate, enhancing its therapeutic efficacy. This enables the targeted delivery of potent drugs to cancer cells, minimizing off-target effects and improving patient outcomes.

Protein Modification: This PEG derivative is employed to modify proteins through PEGylation, which involves attaching PEG chains to proteins to improve their pharmacokinetic properties. PEGylation can enhance the solubility, stability, and half-life of therapeutic proteins, thereby improving their efficacy. This application is crucial for the development of better biologic drugs for various diseases including arthritis and diabetes.

Nanoparticle Functionalization: CHO-Ph-CONH-PEG9-amine is used to functionalize the surface of nanoparticles, conferring them with stealth properties to evade the immune system. This functionalization improves the biodistribution and therapeutic performance of nanoparticles in drug delivery applications. The PEGylated nanoparticles can carry drugs or imaging agents, enabling targeted and efficient treatment or diagnosis of diseases.

Surface Coating: It is also utilized in the surface coating of biomedical devices and implants to enhance biocompatibility and reduce immunogenicity. The PEG chains provide a hydrophilic barrier, minimizing protein adsorption and cell adhesion, which can lead to reduced inflammation and fibrosis. This application is vital for the development of long-lasting and safe medical implants such as stents and catheters.

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