CHO-Ph-CONH-PEG8-amine

CHO-Ph-CONH-PEG8-amine (CHO-Phenylamide-PEG8-Amine) is a chemical reagent especially useful in bioconjugation and cross-linking applications. Here are some key applications of CHO-Ph-CONH-PEG8-amine:

Protein Labeling: CHO-Ph-CONH-PEG8-amine can be used to label proteins with various probes or tags. The amine group reacts with NHS-esters or other electrophiles, facilitating the linkage of labels to specific amino acid residues on proteins. This is essential for studying protein localization, interactions, and function in biological systems.

Drug Delivery: This compound serves as a linker in drug conjugation strategies, where a therapeutic agent is attached to a targeting molecule such as an antibody. The PEG8 spacer provides flexibility and reduces steric hindrance, improving the pharmacokinetic properties of the drug conjugate. This results in enhanced delivery and efficacy of the therapeutic agent.

Nanoparticle Functionalization: CHO-Ph-CONH-PEG8-amine can be used to functionalize nanoparticles for targeted delivery or imaging purposes. The amine group allows for the conjugation of biomolecules or targeting ligands, while the PEG8 chain imparts solubility and biocompatibility to the nanoparticles. This enhances the specificity and stability of nanoparticle-based systems in biomedical applications.

Surface Modification: In biosensor development, this compound can be utilized to modify surfaces to capture specific analytes. The amine functionality enables the attachment of recognition elements such as antibodies or aptamers onto sensor surfaces. This enhances the detection sensitivity and selectivity of the biosensing platforms for various analytical applications.