CHO-Ph-CONH-PEG5-NHS ester

Name: CHO-Ph-CONH-PEG5-NHS ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

Cat No.: BPG-1498

Purity: ≥95%

4.5

CHO-Ph-CONH-PEG5-NHS ester is a non-cleavable 5-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).

Category	CHO-Ph-CONH-PEGn-NHS ester
Molecular Formula	C25H34N2O11
Molecular Weight	538.55
Storage	Store at 2-8°C

Structure of CHO-Ph-CONH-PEG5-NHS ester

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Specification
Key Product Attributes
Reaction & Conjugation Properties
Application

Synonyms	Ald-Ph-PEG5-NHS ester; Ald-Ph-PEG5-NHS; Ald-Ph-amido-PEG5-C2-NHS ester; DF-PEG5-NHS; 2,5-dioxopyrrolidin-1-yl 1-(4-formylphenyl)-1-oxo-5,8,11,14,17-pentaoxa-2-azaicosan-20-oate
IUPACName	(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
CanonicalSMILES	O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCNC(C2=CC=C(C=O)C=C2)=O
InChI	InChI=1S/C25H34N2O11/c28-19-20-1-3-21(4-2-20)25(32)26-8-10-34-12-14-36-16-18-37-17-15-35-13-11-33-9-7-24(31)38-27-22(29)5-6-23(27)30/h1-4,19H,5-18H2,(H,26,32)
InChIKey	XEFOIHVWNGWHAT-UHFFFAOYSA-N
Purity	≥95%

PEGType	Discrete PEG Linker
PEGArchitecture	Linear
Functionality	Heterobifunctional

ReactiveToward	Aminooxy Groups; Hydrazides / Hydrazines; Primary Amines
ReactionChemistry	Oxime Ligation; Hydrazone Formation; Reductive Amination; Activated-Ester Amine Coupling
BiomoleculeCompatibility	Carbonyl-Reactive Proteins / Peptides; Glycans / Oxidized Glycoproteins; Aminooxy- or Hydrazide-Modified Oligonucleotides; Proteins / Antibodies; Peptides; Amine-Modified Oligonucleotides
ResearchUse	Amine-Selective Biomolecule Coupling; Carbonyl–Aminooxy Oxime Ligation; Carbonyl–Hydrazide Ligation

CHO-Ph-CONH-PEG5-NHS ester is a functionalized compound with a variety of applications in bioscience and bioengineering. Here are some key applications of CHO-Ph-CONH-PEG5-NHS ester:

Bioconjugation: CHO-Ph-CONH-PEG5-NHS ester is extensively used for the bioconjugation of proteins, peptides, and other biomolecules. This reagent allows for the stable attachment of biomolecules to surfaces or other proteins via amine groups. Such conjugates are vital in creating targeted therapeutics, diagnostic tools, and advanced research reagents.

Drug Delivery: In drug delivery systems, CHO-Ph-CONH-PEG5-NHS ester plays a crucial role in enhancing the solubility and stability of drug molecules. By pegylating therapeutic agents, it improves their pharmacokinetic properties, such as reducing immunogenicity and prolonging circulation time in the bloodstream. This leads to more efficient and targeted delivery of drugs, especially in cancer therapies.

Surface Modification: This compound is used in the modification of surfaces in biosensors, microarrays, and other diagnostic devices. The functional groups can be covalently attached to surface amines, creating a biocompatible interface that improves detection sensitivity and specificity. Such modifications are critical for developing high-performance diagnostic and analytical tools.

Tissue Engineering: In tissue engineering, CHO-Ph-CONH-PEG5-NHS ester is used to functionalize biomaterial scaffolds. By attaching functional molecules to scaffolds, researchers can promote cell adhesion, proliferation, and differentiation. This application is important for developing advanced materials for regenerative medicine and synthetic tissue constructs.