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CbzNH-PEG10-CH2CH2NH2

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Category	CbzNH-PEGn-CH2CH2NH2
Catalog NO.	BPG-0158
Product Name	CbzNH-PEG10-CH2CH2NH2
Molecular Formula	C30H54N2O12
Molecular Weight	634.76

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Description	CbzNH-PEG10-CH2CH2NH2 is a PEG linker containing an amine group and a benzyl (Cbz) protecting group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.
Synonyms	benzyl (32-amino-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontyl)carbamate
IUPAC Name	benzyl N-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate
Canonical SMILES	O=C(OCC1=CC=CC=C1)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
InChI	InChI=1S/C30H54N2O12/c31-6-8-34-10-12-36-14-16-38-18-20-40-22-24-42-26-27-43-25-23-41-21-19-39-17-15-37-13-11-35-9-7-32-30(33)44-28-29-4-2-1-3-5-29/h1-5H,6-28,31H2,(H,32,33)
InChIKey	FXXQGDPGYUSIMA-UHFFFAOYSA-N
Purity	≥95%
Storage	Store at 2-8°C

CbzNH-PEG10-CH2CH2NH2 is a bifunctional polyethylene glycol (PEG) derivative widely used in various scientific applications. Here are some key applications of CbzNH-PEG10-CH2CH2NH2:

Drug Delivery Systems: CbzNH-PEG10-CH2CH2NH2 is utilized in the development of advanced drug delivery systems. Its PEGylation helps to enhance the solubility, stability, and bioavailability of therapeutic molecules. The bifunctional ends enable conjugation with drugs and targeting agents, leading to improved targeting and reduced side effects.

Bioconjugation: This PEG derivative is often used in bioconjugation techniques to link biomolecules such as proteins, peptides, and antibodies. The CbzNH group protects the amine, allowing for selective deprotection and subsequent functionalization. This versatility makes it invaluable in creating multifunctional biomolecular complexes for research and therapeutic applications.

Surface Modifications: CbzNH-PEG10-CH2CH2NH2 is employed in modifying surfaces to improve biocompatibility and reduce non-specific binding. It's commonly used to coat medical devices, biosensors, and other diagnostic tools. The PEGylation imparts a hydrophilic layer, minimizing protein adsorption and cellular adhesion.

Nanoparticle Functionalization: In nanotechnology, CbzNH-PEG10-CH2CH2NH2 is used to functionalize nanoparticles for targeted drug delivery or imaging. The PEGylation enhances the circulation time and reduces immunogenicity, while the amine and CbzNH groups facilitate the attachment of targeting ligands or therapeutic agents. This improves the efficacy and specificity of nanoparticle-based therapies.

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