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Bromo-PEG7-alcohol

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Category Small-molecule Heterobifunctional PEG
Catalog NO. BPG-2069
Product Name Bromo-PEG7-alcohol
CAS 86220-35-1
Molecular Formula C14H29BrO7
Molecular Weight 389.28
Bromo-PEG7-alcohol
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Product Information

Description Bromo-PEG7-alcohol is a polyethylene glycol (PEG)-based PROTAC linker. Bromo-PEG7-alcohol can be used in the synthesis of a series of PROTACs.
Synonyms Br-PEG7-OH; 20-Bromo-3,6,9,12,15,18-hexaoxaicosan-1-ol; 3,6,9,12,15,18-Hexaoxaeicosan-1-ol, 20-bromo-
IUPAC Name 2-[2-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES C(COCCOCCOCCOCCOCCOCCBr)O
InChI InChI=1S/C14H29BrO7/c15-1-3-17-5-7-19-9-11-21-13-14-22-12-10-20-8-6-18-4-2-16/h16H,1-14H2
InChIKey PVCTXGYCIVAGIV-UHFFFAOYSA-N
Boiling Point 443.0±40.0°C at 760 mmHg
Purity ≥95%
Density 1.3±0.1 g/cm3
Appearance Liquid
Storage Store at 2-8°C

Bromo-PEG7-alcohol, a compound renowned for its functional groups and polyethylene glycol (PEG) structure, finds diverse applications in both scientific and industrial settings. Here are four key applications of Bromo-PEG7-alcohol presented with a high degree of perplexity and burstiness:

Bioconjugation: Widely employed in bioconjugation procedures, Bromo-PEG7-alcohol acts as a crucial element for linking biomolecules, such as proteins and antibodies, to various surfaces or molecules. This PEG linker plays a pivotal role in enhancing solubility and biocompatibility, making it an ideal choice for crafting drug delivery systems or diagnostic tools. The presence of the bromo group facilitates precise attachment to target molecules, ensuring stable and accurate conjugation.

Polymer Synthesis: Within the realm of polymer chemistry, Bromo-PEG7-alcohol emerges as an indispensable building block for synthesizing branched or amphiphilic polymers. These polymers serve a multitude of purposes, ranging from drug delivery to hydrogel formation and nanostructure construction. The hydrophilic PEG chain inherent in Bromo-PEG7-alcohol elevates the solubility and biocompatibility of these polymers, expanding their application in biomedicine and materials science.

Surface Modification: Leveraging the unique properties of Bromo-PEG7-alcohol, researchers can modify the surfaces of nanoparticles or other materials to enhance their characteristics. By attaching PEG chains to these surfaces, nonspecific binding is reduced and circulation time in biological systems is extended. This method proves invaluable in the development of stealth nanoparticles for drug delivery and imaging applications, ultimately enhancing their efficacy and safety profiles.

Chemical Synthesis Intermediates: In the realm of organic chemistry, Bromo-PEG7-alcohol serves as a crucial intermediate for synthesizing intricate molecular structures. The reactive bromo group undergoes various substitution reactions, making it a versatile tool for constructing tailored chemical arrangements. This versatility positions Bromo-PEG7-alcohol as an essential component in the creation of novel pharmaceuticals, catalysts, or specialized materials, driving innovation in chemical synthesis.

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