BrCH2CONH-PEG7-OMe
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| Category | BrCH2CONH-PEGn-OMe |
| Catalog NO. | BPG-0141 |
| Product Name | BrCH2CONH-PEG7-OMe |
| Molecular Formula | C19H38BrNO9 |
| Molecular Weight | 504.42 |
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| Description | BrCH2CONH-PEG7-OMe is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of a series of PROTACs. |
| Synonyms | 2-bromo-N-(2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl)acetamide |
| IUPAC Name | 2-bromo-N-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]acetamide |
| Canonical SMILES | O=C(NCCOCCOCCOCCOCCOCCOCCOCCOC)CBr |
| InChI | InChI=1S/C19H38BrNO9/c1-23-4-5-25-8-9-27-12-13-29-16-17-30-15-14-28-11-10-26-7-6-24-3-2-21-19(22)18-20/h2-18H2,1H3,(H,21,22) |
| InChIKey | FSJSIZJGHJNXJZ-UHFFFAOYSA-N |
| Purity | ≥95% |
| Storage | Store at 2-8°C |
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BrCH2CONH-PEG7-OMe is a polyethylene glycol (PEG) derivative with a bromomethyl group. This versatile compound finds numerous applications in the bioscience industry. Here are some key applications of BrCH2CONH-PEG7-OMe: Targeted Drug Delivery: BrCH2CONH-PEG7-OMe is used in the development of targeted drug delivery systems. By attaching therapeutic agents to the PEG linkage, it enhances solubility and stability while reducing immunogenicity. This helps in directing drugs to specific tissues or cells, improving efficacy and reducing side effects. Bioconjugation: This PEG derivative is an essential reagent for bioconjugation, the process of chemically linking biomolecules for various applications. It can be used to attach proteins, peptides, and other biomolecules to surfaces or other molecules. This enables the creation of advanced diagnostic tools, biosensors, and therapeutic agents. Protein Modification: BrCH2CONH-PEG7-OMe is employed to modify proteins by attaching the PEG moiety, a process known as PEGylation. PEGylation enhances protein stability, solubility, and half-life, making proteins more suitable for therapeutic use. For example, PEGylated enzymes can be used for extended release formulations in drug delivery. Surface Coating: In biotechnology and medical device industries, BrCH2CONH-PEG7-OMe is used to coat surfaces to create non-fouling and biocompatible materials. By applying a PEG layer, it can prevent protein adsorption and cell adhesion on medical implants and diagnostic devices. This helps in maintaining device functionality and reduces adverse immune responses. |
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Industry News
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PEGylation of Peptides
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Reduce the Immunogenicity of Peptide/Protein Drugs
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