Br-PEG5-CH2COOH

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Category	Br-PEGn-CH2COOH
Catalog NO.	BPG-1423
Product Name	Br-PEG5-CH2COOH
CAS	2098982-48-8
Molecular Formula	C12H23BrO7
Molecular Weight	359.21

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Description	Br-PEG5-CH2COOH is a PEG linker containing a bromide group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions.
Synonyms	Bromo-PEG5-CH2CO2H; Bromo-PEG5-acetic acid; 17-Bromo-3,6,9,12,15-pentaoxaheptadecan-1-oic acid; Acetic acid, 2-[(14-bromo-3,6,9,12-tetraoxatetradec-1-yl)oxy]-; 3,6,9,12,15-Pentaoxaheptadecan-1-oic acid, 17-bromo-
IUPAC Name	2-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
Canonical SMILES	C(COCCOCCBr)OCCOCCOCC(=O)O
InChI	InChI=1S/C12H23BrO7/c13-1-2-16-3-4-17-5-6-18-7-8-19-9-10-20-11-12(14)15/h1-11H2,(H,14,15)
InChIKey	FOQREKYOJJILHI-UHFFFAOYSA-N
Boiling Point	450.7±40.0°C (Predicted)
Purity	≥95%
Density	1.349±0.06 g/cm3 (Predicted)
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

Br-PEG5-CH2COOH, a specialized compound with diverse biotechnological and pharmaceutical applications, plays a pivotal role in the following key areas, presented with high perplexity and burstiness:

Drug Delivery Systems: Utilizing Br-PEG5-CH2COOH enhances the solubility and stability of drug molecules, a critical aspect in drug development. By conjugating drugs with this compound, researchers can optimize the pharmacokinetics and bioavailability of therapeutic agents, leading to the potential for more potent and precisely targeted disease treatments.

Bioconjugation: In the intricate realm of protein and peptide bioconjugation, the unique composition of Br-PEG5-CH2COOH serves as a valuable tool. With both carboxyl and bromo groups, this compound enables the attachment of biomolecules to diverse surfaces and molecules, fostering the creation of innovative diagnostic tools and targeted therapies, critical for advancing modern biomedicine.

Surface Modification: Br-PEG5-CH2COOH plays a crucial role in modifying the surfaces of nanoparticles and other delivery vehicles, offering significant benefits in biomedicine. By modulating surface properties, this compound can mitigate immunogenic responses and enhance circulation time in the bloodstream, essential for the development of safe and effective nanomedicines poised to revolutionize healthcare.

Polymer Synthesis: Within the realm of polymer chemistry, Br-PEG5-CH2COOH facilitates the incorporation of functional groups into polymer chains, sparking innovation in material science. This enables the creation of tailor-made polymers with distinct properties like heightened hydrophilicity or altered mechanical strength, with applications spanning medical devices, tissue engineering, and advanced materials at the forefront of cutting-edge research and development.

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