| Category | COOH-PEGn-COOH |
| Molecular Formula | C14H26O9 |
| Molecular Weight | 338.35 |
| Appearance | Pale Yellow or Colorless Oily Liquid |
| Shipping | Room temperature in continental US; may vary elsewhere. |
| Storage | Store at 2-8°C |
Bis-PEG5-acid
4.5
Bis-PEG5-acid is a polyethylene glycol (PEG)-based PROTAC linker. Bis-PEG5-acid can be used in the synthesis of a series of PROTACs.
Structure of 439114-13-3
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- Specification
- Key Product Attributes
- Reaction & Conjugation Properties
| Synonyms | α,ω-dipropionic acid tetraethylene glycol; HOOCCH2CH2O-PEG4-CH2CH2COOH; 4,7,10,13,16-Pentaoxanonadecanedioic Acid; 4,7,10,13,16-Pentaoxanonadecane-1,19-dioic acid |
| IUPACName | 3-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
| CanonicalSMILES | C(COCCOCCOCCOCCOCCC(=O)O)C(=O)O |
| InChI | InChI=1S/C14H26O9/c15-13(16)1-3-19-5-7-21-9-11-23-12-10-22-8-6-20-4-2-14(17)18/h1-12H2,(H,15,16)(H,17,18) |
| InChIKey | VRTJBJNTMHDBAI-UHFFFAOYSA-N |
| BoilingPoint | 513.6±50.0 °C at 760 mmHg |
| Purity | 95% |
| Density | 1.205±0.06 g/cm3 (Predicted) |
| Solubility | Soluble in DMSO |
| RelatedCAS | 51178-68-8 (polymer) |
| Application | A dicarboxylic acid used in the preparation of potent dimeric inhibitors of the PSD-95-NMDA receptor interaction. |
| Pictogram | Corrosive |
| Signal | Danger |
| PrecautionaryStatementCodes | P264+P265, P280, P305+P354+P338, and P317 |
| PEGType | Discrete PEG Linker |
| PEGArchitecture | Linear |
| Functionality | Homobifunctional |
| ReactiveToward | Primary Amines (after activation) |
| ReactionChemistry | Carbodiimide-Mediated Amide Coupling (EDC/NHS) |
| BiomoleculeCompatibility | Proteins / Antibodies; Peptides; Amine-Modified Oligonucleotides |
| Application | A dicarboxylic acid used in the preparation of potent dimeric inhibitors of the PSD-95-NMDA receptor interaction. |
| ResearchUse | Carboxyl-to-Amine Coupling after Activation; Amide Bond Formation |
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