Bis-PEG5-acetic acid

Name: Bis-PEG5-acetic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 77855-76-6

Cat No.: BPG-2011

Purity: ≥95%

4.5

PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. PEG6-(CH2CO2H)2 is a PEG derivative containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Category	COOH-CH2-PEGn-CH2-COOH
Molecular Formula	C14H26O10
Molecular Weight	354.35
Appearance	Colorless Oily Liquid
Shipping	Room temperature in continental US; may vary elsewhere
Storage	Store at 2-8°C

Structure of 77855-76-6

Ordering Information

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Specification

Synonyms	COOH-CH2-PEG6-CH2-COOH; COOH-CH2-PEG5-CH2-COOH; 3,6,9,12,15,18-Hexaoxaeicosanedioic acid; 3,6,9,12,15,18-Hexaoxaicosane-1,20-dioic acid
IUPACName	2-[2-[2-[2-[2-[2-(carboxymethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
CanonicalSMILES	C(COCCOCCOCC(=O)O)OCCOCCOCC(=O)O
InChI	InChI=1S/C14H26O10/c15-13(16)11-23-9-7-21-5-3-19-1-2-20-4-6-22-8-10-24-12-14(17)18/h1-12H2,(H,15,16)(H,17,18)
InChIKey	DCQRSABUSOYSIY-UHFFFAOYSA-N
BoilingPoint	524.8±45.0 °C at 760 mmHg
Purity	≥95%
Density	1.234±0.06 g/cm3 (Predicted)
Solubility	Soluble in DMSO, Water