Bis-PEG3-NHS Ester

Name: Bis-PEG3-NHS Ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 1314378-16-9

Cat No.: BPG-3568

Purity: ≥98%

4.5

Bis-PEG3-NHS Ester is a PEG-based spacer and synthetic linker building block used to introduce a defined hydrophilic and flexible segment into multistep conjugation designs. The PEG chain can increase molecular spacing and provide a modular connection between reactive groups without serving as a dedicated cleavage trigger. This derivative contains peg3 spacer together with terminal functionality selected for further synthesis. The available reactive group is nhs/succinimidyl ester (amine-reactive) for antibody lysines/primary amines. The opposite terminus provides terminal peg functionality depends on the specific derivative; additional activation may be required. Coupling and deprotection conditions should be matched to the terminal groups and the intended order of assembly.

Category	Bis-PEGn-NHS ester
Molecular Formula	C18H24N2O11
Molecular Weight	444.39
Appearance	Pale Yellow or Colorless Oily Matter
Shipping	Room temperature, or blue ice upon request.
Storage	Store at 2-8°C

Structure of 1314378-16-9

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Specification

Synonyms	α,ω-disuccinimidyl diethylene glycol; bis(2,5-dioxopyrrolidin-1-yl) 3,3'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))dipropanoate; 1,1'-Bis(2,5-dioxo-1-pyrrolidinyl) 3,3'-[oxybis(2,1-ethanediyloxy)]bis[propanoate]; Propanoic acid, 3,3'-[oxybis(2,1-ethanediyloxy)]bis-, 1,1'-bis(2,5-dioxo-1-pyrrolidinyl) ester; 1,1'-{Oxybis[2,1-ethanediyloxy(1-oxo-3,1-propanediyl)oxy]}di(2,5-pyrrolidinedione); 2,5-Pyrrolidinedione, 1,1'-[oxybis[2,1-ethanediyloxy(1-oxo-3,1-propanediyl)oxy]]bis-; NHS-PEG3-NHS
IUPACName	(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]propanoate
CanonicalSMILES	C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCC(=O)ON2C(=O)CCC2=O
InChI	InChI=1S/C18H24N2O11/c21-13-1-2-14(22)19(13)30-17(25)5-7-27-9-11-29-12-10-28-8-6-18(26)31-20-15(23)3-4-16(20)24/h1-12H2
InChIKey	OPGNUERFYQLUNP-UHFFFAOYSA-N
BoilingPoint	577.4±60.0°C (Predicted)
Purity	≥98%
Density	1.42±0.1 g/cm3 (Predicted)
Solubility	Soluble in DMSO
RelatedCAS	123502-57-8 (polymer)