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Biotin-PEG5-azide

CAS No. CAS No.: 1163732-89-5
Cat No. Cat No.: BPG-2309
Purity Purity: >97%
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Biotin-PEG5-azide is a polyethylene glycol (PEG)-based PROTAC linker. Biotin-PEG5-azide can be used in the synthesis of a series of PROTACs.

Category Small-molecule Biotin PEG
Molecular Formula C₂₂H₄₀N₆O₇S
Molecular Weight 532.65
Appearance White Solid
Shipping Room temperature in continental US; may vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Biotin-PEG5-azide

Structure of 1163732-89-5

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  • Specification
  • Key Product Attributes
  • Reaction & Conjugation Properties
Synonyms (+)-Biotin-PEG5-CH2CH2N3
IUPACName 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide
CanonicalSMILES C1C2C(C(S1)CCCCC(=O)NCCOCCOCCOCCOCCOCCN=[N+]=[N-])NC(=O)N2
InChI InChI=1S/C22H40N6O7S/c23-28-25-6-8-32-10-12-34-14-16-35-15-13-33-11-9-31-7-5-24-20(29)4-2-1-3-19-21-18(17-36-19)26-22(30)27-21/h18-19,21H,1-17H2,(H,24,29)(H2,26,27,30)/t18-,19-,21-/m0/s1
InChIKey MKXKDMBFPMTVAW-ZJOUEHCJSA-N
Purity >97%
PEGType Discrete PEG Linker
PEGArchitecture Linear
Functionality Monofunctional (Reactive)
ReactiveToward Terminal Alkynes; Strained Alkynes (DBCO/BCN)
ReactionChemistry CuAAC Click Chemistry; SPAAC Click Chemistry
BiomoleculeCompatibility Biotin/Avidin Affinity Systems; Click-Handle-Modified Proteins / Peptides; Click-Handle-Modified Antibodies; Click-Handle-Modified Oligonucleotides; Small Molecules / Probes
ResearchUse Copper-Free Azide–Cyclooctyne Ligation; Copper-Catalyzed Azide–Alkyne Ligation; Biotin / Desthiobiotin Affinity-Probe Construction

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