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Biotin-PEG2-acid

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Category	Biotin PEG
Catalog NO.	BPG-2095
Product Name	Biotin-PEG2-acid
CAS	1365655-89-5
Molecular Formula	C17H29N3O6S
Molecular Weight	403.49

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Description	Biotin-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms	(+)-Biotin-PEG2-acid; (+)-Biotin-PEG2-COOH; 3-(2-(2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethoxy)propanoic acid
IUPAC Name	3-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]propanoic acid
Canonical SMILES	C1C2C(C(S1)CCCCC(=O)NCCOCCOCCC(=O)O)NC(=O)N2
InChI	InChI=1S/C17H29N3O6S/c21-14(18-6-8-26-10-9-25-7-5-15(22)23)4-2-1-3-13-16-12(11-27-13)19-17(24)20-16/h12-13,16H,1-11H2,(H,18,21)(H,22,23)(H2,19,20,24)/t12-,13-,16-/m0/s1
InChIKey	SDOAIZRTYJIBBG-XEZPLFJOSA-N
Boiling Point	752.2±60.0 °C at 760 mmHg
Flash Point	408.7±32.9 °C
Purity	>98.0%
Density	1.2±0.1 g/cm3
Solubility	10 mm in DMSO
Appearance	Solid
Shelf Life	-20°C 3 years powder; -80°C 2 years in solvent
Storage	-20°C
Vapor Pressure	0.0±5.4 mmHg at 25°C
LogP	-1.05

Biotin-PEG2-acid, a versatile compound with diverse applications in biochemical and medical research, is highly esteemed for its exceptional biotinylation properties and PEG linker. Below are four key applications, portrayed with a high degree of perplexity and burstiness:

Protein Labeling: Positioned as a pivotal element in molecular investigations, Biotin-PEG2-acid assumes a crucial role in tagging proteins with biotin, augmenting their detectability and quantifiability across a broad spectrum of assays. Through robust biotin-avidin or biotin-streptavidin interactions, this compound ensures precise and enduring binding. This methodology underpins crucial techniques like Western blotting, immunoprecipitation, and ELISA, propelling progress in protein analysis and molecular biology to new heights.

Drug Delivery: Spearheading the realm of targeted therapeutics, Biotin-PEG2-acid contributes to personalized drug delivery systems where biotinylated drugs or nanoparticles selectively adhere to biotin receptors on target cells. This targeted paradigm amplifies drug efficacy while mitigating adverse effects. With the PEG spacer enhancing flexibility, the pharmacokinetics and biodistribution of therapeutic agents are optimized, heralding a new era in precision medicine characterized by tailored treatments.

Imaging: Harnessing the potential of molecular imaging, Biotin-PEG2-acid emerges as an indispensable component when combined with imaging agents to elevate their specificity and resolution. This conjugation enables meticulous visualization and localization of biotin-tagged molecules within biological tissues. From fluorescence microscopy to magnetic resonance imaging (MRI) and positron emission tomography (PET) scans, the applications of Biotin-PEG2-acid in imaging technologies are vast, revolutionizing diagnostic precision and research efficacy to unprecedented levels.

Surface Coating: Redefining the landscape of surface engineering, Biotin-PEG2-acid demonstrates its utility in coating surfaces with biotin to establish biotinylated platforms for biosensors, microarrays, and analytical instruments. This biotinylation strategy facilitates the selective capture of streptavidin-tagged biomolecules, enabling highly specific and sensitive detection methods. Such technological strides, pivotal in diagnostics, high-throughput screening, and bioanalytical research, underscore the transformative potential of Biotin-PEG2-acid in sculpting the future of biomedical sciences.

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