Benzyl-PEG9-NH2

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Category	Benzyl-PEGn-NH2
Catalog NO.	BPG-1216
Product Name	Benzyl-PEG9-NH2
CAS	868594-50-7
Molecular Formula	C25H45NO9
Molecular Weight	503.63

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Description	Benzyl-PEG9-NH2 is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of a series of PROTACs.
Synonyms	Benzyl-PEG9-amine; BnO-PEG8-CH2CH2NH2; 1-Phenyl-2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-amine; 1-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]-2-[2-[2-[2-[2-(benzyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethane; 3,6,9,12,15,18,21,24,27-Nonaoxaoctacosan-1-amine, 28-phenyl-
IUPAC Name	2-[2-[2-[2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Canonical SMILES	C1=CC=C(C=C1)COCCOCCOCCOCCOCCOCCOCCOCCOCCN
InChI	InChI=1S/C25H45NO9/c26-6-7-27-8-9-28-10-11-29-12-13-30-14-15-31-16-17-32-18-19-33-20-21-34-22-23-35-24-25-4-2-1-3-5-25/h1-5H,6-24,26H2
InChIKey	LLFJEMCZSIYOES-UHFFFAOYSA-N
Boiling Point	567.8±45.0°C (Predicted)
Purity	≥95%
Density	1.085±0.06 g/cm3 (Predicted)
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

Benzyl-PEG9-NH2 is a functionalized polyethylene glycol (PEG) compound used in various bioconjugation applications. Here are some key applications of Benzyl-PEG9-NH2:

Drug Delivery: Benzyl-PEG9-NH2 is commonly employed in the development of drug delivery systems. The PEGylation process can improve the solubility, stability, and pharmacokinetic properties of therapeutic agents. This enhances the efficacy of drug delivery by increasing their half-life in the bloodstream and reducing immunogenicity.

Bioconjugation: This compound is ideal for linking bioactive molecules such as peptides, proteins, and small molecules to surfaces or carriers. The amine group of Benzyl-PEG9-NH2 can react with various coupling agents to facilitate these connections. Such bioconjugates are useful for creating targeted therapies, diagnostics, and imaging agents.

Surface Modification: Benzyl-PEG9-NH2 can be used to modify the surfaces of nanoparticles and biomaterials to improve biocompatibility. PEGylation of surfaces can minimize protein adsorption and cell adhesion, which is crucial for applications such as medical implants and biosensors. This ensures that the materials remain inert and functional within biological environments.

Chemical Biology: In chemical biology, Benzyl-PEG9-NH2 is used to study protein interactions and cellular processes. The PEGylation can create a more hydrophilic environment, enabling better solubility and stability of proteins under study. This can help in elucidating mechanisms of action and interaction of various biomolecules.

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