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Benzyl-PEG1-N3

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Category Benzyl-PEGn-N3
Catalog NO. BPG-1211
Product Name Benzyl-PEG1-N3
CAS 66021-75-8
Molecular Formula C9H11N3O
Molecular Weight 177.21
Benzyl-PEG1-N3
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Product Information

Description Benzyl-PEG1-N3 is a PEG linker with an acid labile, benzyl protecting group. The azide can participate in copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN moieties. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Synonyms Benzyl-PEG1-Azide; Benzyl 2-azidoethyl ether; 2-Benzyloxyethyl azide; Benzene, [(2-azidoethoxy)methyl]-
IUPAC Name 2-azidoethoxymethylbenzene
Canonical SMILES C1=CC=C(C=C1)COCCN=[N+]=[N-]
InChI InChI=1S/C9H11N3O/c10-12-11-6-7-13-8-9-4-2-1-3-5-9/h1-5H,6-8H2
InChIKey JNNJRIJFTCBFLX-UHFFFAOYSA-N
Purity ≥95%
Appearance Pale Yellow or Colorless Oily Matter
Storage Store at 2-8°C

Benzyl-PEG1-N3, a versatile reagent prevalent in bioscience, finds prominent utility in bioconjugation and medicinal chemistry:

Bioconjugation: In the realm of biomolecular conjugation, Benzyl-PEG1-N3 emerges as a pivotal player, facilitating the linkage of functional groups to proteins, peptides, and other macromolecules. This reagent's prowess lies in enhancing the solubility and stability of bioconjugates, thereby serving as a linchpin in the advancement of biotherapeutics and diagnostic tools.

Click Chemistry: At the crux of click chemistry reactions, Benzyl-PEG1-N3 stands out as a linchpin, enabling the precise and efficient coupling of azide-containing molecules with alkyne-functionalized counterparts. This high-performance ligation technique finds widespread application in drug discovery, materials science, and molecular imaging, fostering the swift and selective assembly of intricate molecular structures.

Drug Delivery: Unfurling its potential in the realm of drug modification, Benzyl-PEG1-N3 shines as a transformative agent, enhancing the pharmacokinetics and bioavailability of therapeutic molecules. The process of PEGylation not only boosts solubility but also curtails the immunogenicity of therapeutics, playing a pivotal role in crafting drug delivery systems that ensure targeted and sustained medication release.

Surface Modification: In the arena of surface engineering, Benzyl-PEG1-N3 emerges as a game-changer, enabling the creation of biocompatible and non-fouling coatings. Through the grafting of PEG chains onto surfaces, this reagent curtails protein adsorption and cell adhesion, rendering it indispensable for medical device and biosensor applications. Its role in crafting materials that seamlessly integrate with biological systems underscores its significance in fostering innovation at the interface of biology and technology.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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PEG linkers For Drug

Improved Circulation Half-Life

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