Azido-PEG6-Br
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Category | Azido-PEGn-Br |
Catalog NO. | BPG-0840 |
Product Name | Azido-PEG6-Br |
CAS | 2062663-64-1 |
Molecular Formula | C14H28BrN3O6 |
Molecular Weight | 414.30 |
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Description | Azido-PEG6-Br is a bifunctional PEG linker with a bromide (Br) group and an azide (N3) group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromide (Br) is a good leaving group for nucleophilic substitution reactions. |
Synonyms | Bromo-PEG6-azide;Bromo-PEG6-Azide; Br-PEG6-N3; N3-PEG6-CH2CH2Br; 1-Azido-20-bromo-3,6,9,12,15,18-hexaoxaicosane; 3,6,9,12,15,18-Hexaoxaeicosane, 1-azido-20-bromo- |
IUPAC Name | 1-azido-2-[2-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethane |
Canonical SMILES | C(COCCOCCOCCOCCOCCOCCBr)N=[N+]=[N-] |
InChI | InChI=1S/C14H28BrN3O6/c15-1-3-19-5-7-21-9-11-23-13-14-24-12-10-22-8-6-20-4-2-17-18-16/h1-14H2 |
InChIKey | LTHQYKLNICEFNE-UHFFFAOYSA-N |
Purity | ≥95% |
Appearance | Pale Yellow or Colorless Oily Matter |
Storage | Store at 2-8°C |
Azido-PEG6-Br is a versatile compound used extensively in bioconjugation and material science. Here are some key applications of Azido-PEG6-Br: Bioconjugation: Azido-PEG6-Br is commonly used to attach biomolecules such as proteins or DNA to other molecules or surfaces via click chemistry. This method ensures a stable and specific linkage, making it invaluable in developing diagnostic assays and therapeutic agents. Its biocompatibility and stability enhance the performance and longevity of the conjugates in biological environments. Drug Delivery Systems: The compound is instrumental in designing advanced drug delivery systems. By incorporating Azido-PEG6-Br into nanoparticles or micelles, researchers can achieve targeted drug delivery, improving the efficacy and reducing the side effects of therapeutics. This targeted approach allows for controlled drug release and enhanced treatment outcomes. Surface Functionalization: In material science, Azido-PEG6-Br is used to modify the surface properties of various materials. It can be used to introduce functional groups onto surfaces, which is crucial for applications such as biosensors and medical implants. The ability to tailor surface properties enhances material interactions with biological systems, leading to better performance and biocompatibility. Protein Labeling and Imaging: Azido-PEG6-Br is utilized in protein labeling for imaging applications. By attaching fluorescent dyes or other imaging markers via click chemistry, researchers can visualize cellular processes and protein interactions with high specificity. This application is pivotal in studying biological mechanisms and developing new diagnostic tools. |
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