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Azido-PEG36-alcohol

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Category Small-molecule Heterobifunctional PEG
Catalog NO. BPG-2672
Product Name Azido-PEG36-alcohol
Molecular Formula C₇₂H₁₄₅N₃O₃₆
Molecular Weight 1628.92
Azido-PEG36-alcohol
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Product Information

Description Azido-PEG36-alcohol is a polyethylene glycol (PEG)-based PROTAC linker. Azido-PEG36-alcohol can be used in the synthesis of a series of PROTACs.
Synonyms N3-PEG36-OH
IUPAC Name 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)N=[N+]=[N-]
InChI InChI=1S/C72H145N3O36/c73-75-74-1-3-77-5-7-79-9-11-81-13-15-83-17-19-85-21-23-87-25-27-89-29-31-91-33-35-93-37-39-95-41-43-97-45-47-99-49-51-101-53-55-103-57-59-105-61-63-107-65-67-109-69-71-111-72-70-110-68-66-108-64-62-106-60-58-104-56-54-102-52-50-100-48-46-98-44-42-96-40-38-94-36-34-92-32-30-90-28-26-88-24-22-86-20-18-84-16-14-82-12-10-80-8-6-78-4-2-76/h76H,1-72H2
InChIKey SCHMRXOEZPHVSM-UHFFFAOYSA-N
Purity >95%
Appearance White Solid
Storage Please store the product under the recommended conditions in the Certificate of Analysis.

Azido-PEG36-alcohol, a versatile compound at the intersection of biochemistry and pharmaceuticals, emerges as a linchpin in a myriad of applications. Delve into its diverse roles, presented with a high degree of perplexity and burstiness.

Bioconjugation: Positioned as the cornerstone of bioconjugation reactions, Azido-PEG36-alcohol serves as a vital link, merging biomolecules like proteins, peptides, and antibodies. The azide group enables bio-orthogonal click chemistry, facilitating the attachment of diverse functional groups while upholding crucial biological processes. This pivotal attribute is essential in crafting precision-targeted drug delivery systems, diagnostic tools, and imaging agents, embodying meticulousness in action.

Drug Delivery Systems: By incorporating the PEG moiety, Azido-PEG36-alcohol significantly enhances the solubility and bioavailability of hydrophobic drugs. Through conjugation with PEGylated molecules, researchers elevate drug stability and prolong circulation time in the bloodstream. This optimization results in targeted and efficacious therapeutic outcomes, minimizing adverse effects and maximizing treatment efficacy through an avant-garde framework.

Surface Modification: Playing a critical role in surface modification, Azido-PEG36-alcohol contributes to enhancing nanoparticles, medical devices, and biosensors. The hydrophilic and non-fouling properties of the PEG chain create a protective shield, inhibiting protein adsorption and immune recognition. This transformation in surface characteristics elevates biocompatibility and extends the functional lifespan of biomedical implants and diagnostic tools, heralding a new era of durability and efficiency in medical technologies.

Proteomics Research: Unveiling its significance in proteomics, Azido-PEG36-alcohol assumes a pivotal role in unraveling intricate protein interactions and functions. Through protein tagging with Azido-PEG36-alcohol, researchers meticulously track and isolate proteins for in-depth analysis, leveraging advanced detection techniques like mass spectrometry. This meticulous process aids in deciphering complex protein networks, identifying potential therapeutic targets, and charting the course for groundbreaking advancements in biomedicine and disease treatment.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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PEG linkers For Drug

Improved Circulation Half-Life

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