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Azido-PEG3-t-butyl ester

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Category	Small-molecule Group Protected PEG
Catalog NO.	BPG-1920
Product Name	Azido-PEG3-t-butyl ester
CAS	252881-73-5
Molecular Formula	C13H25N3O5
Molecular Weight	303.35

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Description	N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
Synonyms	N3-PEG3-CH2CH2COOtBu;N3-PEG3-tBu; N3-PEG3-CH2CH2-Boc; 3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoic acid 1,1-dimethylethyl ester; tert-Butyl 12-azido-4,7,10-trioxadocecanoate; 12-Azido-4,7,10-trioxadodecanoic acid tert-butyl ester; 2-Methyl-2-propanyl 3-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}propanoate; Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
IUPAC Name	tert-butyl 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]propanoate
Canonical SMILES	CC(C)(C)OC(=O)CCOCCOCCOCCN=[N+]=[N-]
InChI	InChI=1S/C13H25N3O5/c1-13(2,3)21-12(17)4-6-18-8-10-20-11-9-19-7-5-15-16-14/h4-11H2,1-3H3
InChIKey	QUSLQIYNPWASRR-UHFFFAOYSA-N
Purity	≥95%
Solubility	Soluble in DMSO (10 mm)
Appearance	Pale Yellow or Colorless Oily Matter
Application	Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. Monodisperse Azido-PEG3-t-butyl ester (N3-PEG3-CH2CH2COOtBu) is a click chemistry reagent containing an azide (N3) and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Shelf Life	0-4°C for short term (days to weeks), or -20°C for long term (months).
Storage	Store at -20°C, keep in dry and avoid sunlight
LogP	1.53106

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