Azido-PEG1-CH2COOH

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Category	Azido-PEGn-CH2COOH
Catalog NO.	BPG-0846
Product Name	Azido-PEG1-CH2COOH
CAS	79598-48-4
Molecular Formula	C4H7N3O3
Molecular Weight	145.12

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Description	Azido-PEG1-CH2CO2H is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.
Synonyms	Azido-PEG1-CH2CO2H;2-azidoethoxyacetic acid; (2-Azidoethyl)oxyacetic Acid; Acetic acid, (2-azidoethoxy)-; N3-PEG1-CH2CO2H; Azido-PEG1-acetic acid
IUPAC Name	2-(2-azidoethoxy)acetic acid
Canonical SMILES	C(COCC(=O)O)N=[N+]=[N-]
InChI	InChI=1S/C4H7N3O3/c5-7-6-1-2-10-3-4(8)9/h1-3H2,(H,8,9)
InChIKey	USTXYASKHZDVMV-UHFFFAOYSA-N
Purity	≥95%
Solubility	Soluble in DCM, Water
Appearance	Yellowish Oily Matter
Storage	Store at 2-8°C

Azido-PEG1-CH2COOH, a widely utilized chemical compound in bioconjugation and pharmaceutical research, offers a multitude of applications characterized by high perplexity and burstiness.

Bioconjugation: In the realm of bioconjugation, Azido-PEG1-CH2COOH emerges as a pivotal player owing to its capacity to functionally tether biomolecules together. Leveraging click chemistry, researchers can seamlessly affix peptides, proteins, or nucleic acids to this compound, heralding a crucial step in crafting targeted drug delivery systems and diagnostic tools with precision.

Pharmaceutical Development: Within the domain of pharmaceutical research, Azido-PEG1-CH2COOH assumes a crucial role in tailoring drug candidates to enhance their solubility, stability, and bioavailability. The incorporation of its PEG component aids in mitigating immunogenic responses and extending the half-life of therapeutic agents, particularly benefiting biologics and intricate drugs necessitating meticulous delivery and controlled release.

Surface Modification: Azido-PEG1-CH2COOH's versatility extends to surface modification applications, where it is instrumental in enhancing the biocompatibility of diverse materials and mitigating non-specific binding occurrences. By affixing this compound to surfaces of medical devices and implants, it serves as a shield against protein adsorption and cellular adhesion, underpinning the development of safer and more efficient biomedical implants.

Chemical Biology: In the dynamic realm of chemical biology, researchers harness the potential of Azido-PEG1-CH2COOH to delve into cellular processes and interactions with unparalleled depth. Through the tagging of biomolecules with this compound, scientists gain the ability to monitor and visualize biological phenomena using fluorescence and other detection techniques. This methodological approach not only facilitates the exploration of complex biological systems but also aids in the revelation of novel biomolecular interactions and functionalities.

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