Acs-PEG2-propargyl

Name: Acs-PEG2-propargyl
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	AcS-PEGn-propargyl
Catalog NO.	BPG-0083
Product Name	Acs-PEG2-propargyl
Molecular Formula	C9H14O3S
Molecular Weight	202.27

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Description	Acs-PEG2-propargyl is a PEG linker containing a sulfur acetyl group and a propargyl moiety. The sulfur acetyl group can be deprotected to produce a thiol compound. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG linker increases the water solubility of the compounds in the aqueous media.
Synonyms	S-acetyl-PEG2-Propargyl; Acetylthio-PEG2-Alkyne; S-acetyl-PEG2-alkyne; S-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl) ethanethioate
IUPAC Name	S-[2-(2-prop-2-ynoxyethoxy)ethyl] ethanethioate
SMILES	CC(SCCOCCOCC#C)=O
InChI	InChI=1S/C9H14O3S/c1-3-4-11-5-6-12-7-8-13-9(2)10/h1H,4-8H2,2H3
InChIKey	RFYHVBJUOFIWEA-UHFFFAOYSA-N
Purity	≥95%
Storage	Store at 2-8°C

Acs-PEG2-propargyl, a versatile molecule widely utilized in bioconjugation and biomedical research, offers a multitude of applications showcased with high perplexity and burstiness.

Click Chemistry: Central to click chemistry reactions, Acs-PEG2-propargyl finds significant use in the copper-catalyzed azide-alkyne cycloaddition (CuAAC). This reaction enables the precise and efficient linkage of biomolecules like proteins, nucleic acids, and small molecules. The inclusion of a PEG spacer in Acs-PEG2-propargyl not only bolsters solubility but also diminishes steric hindrance, thereby facilitating successful conjugations.

Drug Delivery Systems: Acs-PEG2-propargyl emerges as a pivotal player in the advancement of drug delivery systems. Through the attachment of therapeutic agents to Acs-PEG2-propargyl, researchers can formulate prodrugs that enhance drug solubility and stability. Moreover, this modification opens avenues for targeted delivery and controlled release, ultimately boosting therapeutic efficacy while mitigating potential side effects.

Bioconjugation: By serving as a linchpin in bioconjugation processes, Acs-PEG2-propargyl fuels the attachment of functional groups to biomolecules, crucial for creating labeled biomolecules in applications spanning imaging, diagnostics, and therapeutics. The alkyne group present in Acs-PEG2-propargyl reacts with azide-tagged molecules to forge stable triazole linkages, ensuring precise and enduring bioconjugations.

Material Science: Acs-PEG2-propargyl takes center stage in crafting functionalized surfaces and hydrogels tailored for diverse biomedical uses. Its capacity to uniformly modify surfaces with bioactive molecules fosters enhanced interactions between materials and biological systems. These tailored materials find utility in diverse fields like tissue engineering, biosensors, and implantable devices, exemplifying the versatility and potential of Acs-PEG2-propargyl in shaping the future of biomedical materials.

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