Acs-PEG12-propargyl

Name: Acs-PEG12-propargyl
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	AcS-PEGn-propargyl
Catalog NO.	BPG-1109
Product Name	Acs-PEG12-propargyl
Molecular Formula	C29H54O13S
Molecular Weight	642.77

Acs-PEG12-propargyl @(data.CAS != null ? $"| CAS " : "") - BOC Sciences

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Description	Acs-PEG12-propargyl is a PEG linker containing a sulfur acetyl group and a propargyl moiety. The sulfur acetyl group can be deprotected to produce a thiol compound. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG linker increases the water solubility of the compounds in the aqueous media.
Synonyms	S-acetyl-PEG12-Propargyl; Acetylthio-PEG12-Alkyne; S-acetyl-PEG12-alkyne; S-(3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacont-38-yn-1-yl) ethanethioate
IUPAC Name	S-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl] ethanethioate
SMILES	CC(SCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC#C)=O
InChI	InChI=1S/C29H54O13S/c1-3-4-31-5-6-32-7-8-33-9-10-34-11-12-35-13-14-36-15-16-37-17-18-38-19-20-39-21-22-40-23-24-41-25-26-42-27-28-43-29(2)30/h1H,4-28H2,2H3
InChIKey	PCSVCGPEQDFJTG-UHFFFAOYSA-N
Purity	≥95%
Storage	Store at 2-8°C

Acs-PEG12-propargyl, a versatile functional molecule, finds diverse applications in scientific realms like bioconjugation and drug delivery. Here are four key applications articulated with elevated perplexity and burstiness:

Bioconjugation: Acs-PEG12-propargyl plays a pivotal role in bioconjugation strategies, facilitating the linkage of biomolecules via click chemistry reactions. With its PEG12 spacer, it offers flexibility and mitigates steric hindrance during the conjugation of proteins, peptides, or antibodies with other entities. This unique capability is instrumental in generating highly precise and stable protein conjugates for biochemical assays and therapeutic interventions, underscoring its indispensable role in molecular interactions and functional analyses.

Drug Delivery Systems: At the forefront of pharmaceutical advancements, Acs-PEG12-propargyl contributes significantly to the design of sophisticated drug delivery systems. Leveraging its propargyl group, it enables click reactions with azide-functionalized drugs or nanoparticles, enabling targeted drug delivery with exceptional precision. This tailored attachment enhances drug solubility, stability, and controlled release dynamics, thereby optimizing therapeutic efficacy and improving patient outcomes through tailored and efficient medication delivery mechanisms.

Surface Functionalization: Acs-PEG12-propargyl is a key player in the realm of surface functionalization across diverse materials such as nanoparticles and biosensors. The PEG12 chain serves to minimize non-specific binding while enhancing the biocompatibility of surfaces—an essential aspect in the development of diagnostic devices and biosensor technologies where surface interactions are paramount. This application underscores the critical role of Acs-PEG12-propargyl in shaping surface properties and influencing molecular interactions to drive innovation in diagnostic and sensing platforms.

Immunoassays: In the domain of immunoassay development, Acs-PEG12-propargyl emerges as a valuable tool for labeling antibodies or antigens with specific tags to amplify detection sensitivity. Its compatibility with click chemistry enables efficient attachment of fluorescent dyes, biotin, or other labels, significantly enhancing the sensitivity and specificity of assays crucial for medical diagnostics and research endeavors. This sophisticated labeling approach underscores the significance of Acs-PEG12-propargyl in enhancing the precision and reliability of immunoassays, pivotal in advancing diagnostic capabilities and research insights within the medical field.

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